Results 191 to 200 of about 26,778 (245)

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Cationic Permethylated Cyclodextrins Capable of Self-Assembling Into Linear Nanostructures in Water. [PDF]

Chemistry
Kolb M, Benjaffel M, Faller P, Raibaut L, Armspach D.   +4 more
europepmc   +1 more source

Carba‐closo‐dodecaborates as Superchaotropic Anions

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
The singly charged boron cluster anion CB11H12– forms strong inclusion complexes with cyclodextrins, interacts strongly with nonionic polymers, and serves as an effective transmembrane carrier, positioning itself as the smallest superchaotropic anion known to date. .
Andrea Barba‐Bon, Guillermo E. Quintero, Maryam Ashjari, Ivana Nikšić‐Franjić, Kai‐Jen Tsung, Xiaojuan Wang, Margarita E. Aliaga, Bohumir Grüner, Werner M. Nau   +8 more
wiley   +1 more source

Modulation of Advanced Glycation End Products and Oxidative Stress by Hesperetin-7-<i>O</i>-Glucoside and Diosmetin-7-<i>O</i>-Glucoside Complexed with Cyclodextrins. [PDF]

Pharmaceuticals (Basel)
Tavares Neto JM, Dos Anjos BS, Macedo JL, de Almeida JOCS, da Silva Pinheiro C, Carvalho FAA, Martins MDCCE, Sousa LDR, Kobayashi J, de Sousa DP, Arcanjo DDR.   +10 more
europepmc   +1 more source

Morphological Transitions in the Self‐Assembly of Rigid Sphere–Rod Amphiphiles Achieved by Adjusting the Linker Length

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
Linker length regulates the self‐assembly of rigid sphere–rod amphiphiles. Long linkers enable rigid sphere–rod molecules to undergo solvent‐dependent conformational switching between I‐ and T‐shaped states, driving morphological transitions of the assemblies from striped spherical structures to onion‐like structures.
Jingfan Wei, Yifan Zhou, Kexing Xiao, Xiangqian Li, Hao Liu, Tianbo Liu   +5 more
wiley   +1 more source

New Fluorescent Probes, Their Spectroscopic Properties, and an Iterative Analysis of Their Complexation with Cyclodextrins. [PDF]

J Phys Chem B
Topa-Skwarczyńska M, Szymaszek P, Chachaj-Brekiesz A, Galek M, Ortyl J, Popielarz R.   +5 more
europepmc   +1 more source

N‐Sulfonyl Azalevoglucosan: A Versatile Platform for the Synthesis of Polysubstituted Piperidines

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
Gain by strain: The synthesis of a levoglucosan analog, in which the pyranose oxygen has been replaced by a nitrogen, allows navigation on the piperidine ring to iteratively install functional groups at C1, C2, C3, C4, and C6 positions using simple experimental protocols with minimal protecting group manipulation.
Dylan Yorga, Jérôme Marrot, Ana Poveda, Nicolas Auberger, Jesús Jiménez‐Barbero, Jérôme Désiré, Yves Blériot   +6 more
wiley   +1 more source

Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol‐Rich Membrane Domains

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen, Nicole Seifert, Patrick Eiring, Johanna Meyer, Hannes Neuweiler, Julia Weingart, Ignacio Vega‐Vásquez, Sören Doose, Philip Kollmannsberger, Markus Sauer   +9 more
wiley   +2 more sources

Cyclodextrin and KR12-Lipopeptide Interactions: A Thermodynamic View of Binding Mechanisms and Impact on the Structure of α-Helical Peptides. [PDF]

J Phys Chem B
Kapica M, Grabowska O, Kamysz E, Kamysz J, Samsonov SA, Wyrzykowski D.   +5 more
europepmc   +1 more source

Performance Optimization and Prospects of Double Network Hydrogels for Flexible Electronic Devices

ChemElectroChem, Volume 13, Issue 20, 16 October 2026.
This review provides a comprehensive overview of DN hydrogels, focusing on their classification, key properties, and diverse applications. Based on crosslinking mechanisms, DN hydrogels are categorized into chemically crosslinked, physically crosslinked, and hybrid crosslinked systems, each offering distinct advantages in stability, reversibility, and ...
Liu Xing, Feng Ailing, Peng Yue, Guo Yating, Liu Yuhui, Li Lanfen, Zu Yanqing, Liu Peitao, Li Xiaodong   +8 more
wiley   +1 more source