Results 171 to 180 of about 12,599 (260)

Predicting enantiomer migration order of levobunolol via sequential computational modeling. [PDF]

J Mol Model
Maia PP, Freitas RMD, Guimarães L, Nascimento CS.   +3 more
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Enhancing bioactivity and bioavailability of Limonium bellidifolium via cyclodextrin-based inclusion complexes: a new strategy in drug discovery from halophyte source. [PDF]

Sci Rep
Ak G, Dall'Acqua S, Sut S, Selvi S, Eyupoglu OE, Zengin G.   +5 more
europepmc   +1 more source

A Zeolitic Pyrimidine Framework (ZPF) Nanoplatform Co‐Delivers a DNAzyme and a Protein Prodrug for Cascade‐Activated Tumour Therapy

Cell Proliferation, EarlyView.
A zeolitic framework co‐delivers a DNAzyme and a protein prodrug to tumour cells and executes a self‐amplifying therapeutic cascade: the DNAzyme elevates tumour oxidative stress to activate a caged RNase A prodrug. This spatiotemporally controlled synergy converts a genetic input into potent enzymatic cytotoxicity, suppressing tumour growth.
Yan Huang, Xingjie Hu, Jinli Sun, Min Yin, Nan Chen   +4 more
wiley   +1 more source

Controlling cyclodextrin host-guest complexation in water with dynamic pericyclic chemistry. [PDF]

Commun Chem
Gaedke M, Ramström A, Pooler DRS, Schaufelberger F.   +3 more
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Cyclodextrin-mediated Enhancement of Haloperidol Solubility: Physicochemical Studies and In Vivo Investigation Using Planaria Worms. [PDF]

Pharm Res
Xiong Y, Shankland K, Khutoryanskiy VV.
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Cyclodextrin-Based Nanocarriers for 5-Fluorouracil: Cholesteryl Modification Enhances Antitumor Activity Against Colorectal Cancer Cells. [PDF]

Int J Nanomedicine
Skonieczna B, Maliszewski B, Wasiluk N, Car H, Wilczewska AZ, Misiak P, Niemirowicz-Laskowska K.   +6 more
europepmc   +1 more source

Smart Coatings Integrating Antimicrobial and Tissue‐Remodeling Functions for Implant Interfaces

Journal of Periodontal Research, EarlyView.
Schematic illustration of a dental implant system showing inflammation around a non‐coated abutment (left) and a stimuli‐responsive coated abutment (right). Acidification associated with inflammation triggers degradation of the PMAA‐based coating, enabling controlled antibiotic release from the LbL system and combating bacterial infection.
Mariana Martins Guerreiro, Amanda Paino Santana, Daniela Moreira Cunha, Gabriel Mulinari‐Santos, Marlise Inêz Klein, Edilson Ervolino, Ludovica Parisi, Martin Degen, Maria Eduarda Fiorentino Ferreira de Andrade, Marta Maria Alves Pereira, Stefany Barbosa Alves da Cruz, Leonardo P. Faverani, Paula Aboud Barbugli, Rodolfo Debone Piazza, Vitória Marega Marchetti, Rodrigo Isaias Lopes Pereira, Rafael Scaf de Molon, Anton Sculean, Erica Dorigatti de Avila   +18 more
wiley   +1 more source