Results 161 to 170 of about 12,599 (260)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Synthesis and Surface Engineering of Two‐Dimensional MXenes for Advanced Functional Applications

The Chemical Record, EarlyView.
This study highlights the synthesis, surface engineering, and advanced functional applications of MXenes, emphasizing key preparation strategies that enable their use in catalysis, energy storage, sensing, and environmental remediation. Two‐dimensional MXenes (2DMxn), a rapidly expanding family of transition metal carbides, nitrides, and carbonitrides ...
Dalil N. H. Al‐Ghubairi, Hadi M. Marwani, Mahmood D. Aljabri, Muhammad Fazle Rabbee, Mohammed Muzibur Rahman   +4 more
wiley   +1 more source

Reduced-Resistances Model for Enhanced Drug Permeation via a Solubilizing Receiver Medium: A Mechanistic Study with Hollow Fiber Membranes. [PDF]

Mol Pharm
Murray JD, Patel RP, Bennett-Lenane H, O'Dwyer PJ, Griffin BT, Polli JE.   +5 more
europepmc   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Recent Advances in Supramolecular Chemistry. [PDF]

Molecules
Geng WC.
europepmc   +1 more source

Sugammadex interference with serum progesterone measurement: an in‐vitro study

Anaesthesia, EarlyView.
Summary Introduction Sugammadex may interfere with serum progesterone immunoassays, potentially rendering measured concentrations and resulting recommendations unreliable. Methods We investigated the effect of a range of sugammadex concentrations on serum progesterone concentrations in samples from pre‐menopausal female volunteers.
Tamblyn Devoy, Theresa Larkin, Miles Allan, Kevin Mantik, Monika McShane, Natalie A. Smith   +5 more
wiley   +1 more source

Mitigating Mucoadhesion of β-Cyclodextrins via PEGylation: Insights from ¹⁹F Diffusion NMR Analysis. [PDF]

Int J Mol Sci
Nguyen KTH, Ba Y.
europepmc   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities. [PDF]

Antioxidants (Basel)
Fenyvesi F, Klusóczki Á, Rusznyák Á, Zsebik B, Bácskay I, Váradi J.   +5 more
europepmc   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, EarlyView.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source