Results 31 to 40 of about 1,766 (177)

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Titanium‐Catalyzed Diastereoselective Keto‐ and Iminonitrile Cyclizations

Chemistry – A European Journal, EarlyView.
The titanium(III)‐catalyzed diastereoselective cyclization of readily‐available substituted ketonitriles gives cyclopentanones in good yield and stereoselectivity. Subsequent 1,2‐addition allows the preparation of cyclopentyls with three consecutive stereocenters.
Christoph Kern, Ritu Singh, Michael A. Unkrig‐Bau, Lukas Jakob, Jan Streuff   +4 more
wiley   +1 more source

Sequential Carboborylation–Suzuki Coupling of α,β‐Unsaturated Tosylhydrazones: A Dual CC Bond‐Forming Strategy for Molecular Diversification

ChemistryEurope
The one‐pot three‐component process involving N‐tosylhydrazones derived from cyclic α,β‐unsaturated ketones, alkylboronic acids, and aryl halides is reported.
Álvaro Valdés‐Maqueda, Manuel Plaza, Carlos Valdés   +2 more
doaj   +1 more source

Organocatalytic Formal (3+2+1)‐Cycloaddition of Allenoates, Michael Acceptors, and Carbaldehydes

Chemistry – A European Journal, EarlyView.
The use of secondary amine Lewis base organocatalysts allows for the unprecedented activation of allenoates for formal (3+2+1)‐cycloadditions with Michael acceptors and aromatic carbaldehydes. ABSTRACT Employing secondary amines as covalently interacting Lewis basic organocatalysts allows for the activation of electron‐deficient allenes (allenoates ...
David Naderer, Alexander Pötscher, Katharina Eder, Uwe Monkowius, Markus Himmelsbach, Mario Waser   +5 more
wiley   +1 more source

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A

Chemistry – A European Journal, EarlyView.
A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger, Maxim Munt, Le Chang, Rositsa Stoykova, Roberto Ojcius, Oliver Spieß, Dieter Schinzer   +6 more
wiley   +1 more source

Catalytic Hydrothermal Liquefaction of Polyethylene With Pt/C to Tune Product Selectivity

CleanMat, EarlyView.
Pt/C‐catalyzed hydrothermal liquefaction of polyethylene in supercritical water enables time‐dependent control of product selectivity, producing paraffin‐rich oils at shorter reaction times and aromatic‐enriched products at longer times without external hydrogen. ABSTRACT Hydrothermal liquefaction (HTL) represents a promising thermochemical pathway for
Taofeng Lu, Wan‐Ting Chen
wiley   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang, Viktoria Lahmann, Jan Philipp Bittner, Pablo Domínguez de María, Sven Jakobtorweihen, Irina Smirnova, Selin Kara   +6 more
wiley   +1 more source

Multidimensional Engineering Enabling Rate‐Matched C−N Coupling for Efficient Organonitrogen Electrosynthesis

EcoEnergy, EarlyView.
This review introduces rate matching as a unifying design principle for efficient electrochemical C−N coupling and highlights multidimensional engineering of catalysts, interfaces, and reactors to synchronize the generation of carbon‐ and nitrogen‐containing intermediates, balance their surface coverages, maximize C−N bond formation, and enable ...
Kaixing Cai, Chunyang Pu, Jun Yang, Guangqin Li, Jiahui Xian   +4 more
wiley   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Chemoselective Aldehyde and Imine Reduction by a Macrocyclic Triazole–Borane Complex Triggered by a Non‐innocent Proton–Hydride Interaction

European Journal of Organic Chemistry, EarlyView.
This work describes the study on a new recyclable reagent, based on a macrocyclic triazole–borane complex. It showed high chemoselectivity for aldehyde reduction and reductive amination over ketones. This selectivity is driven by a noncovalent hydride–proton interaction that stabilizes the transition state for aldehydes but is sterically inhibited in ...
Luca Di Marino, Artur Brotons Rufes, Rosaria Schettini, Giorgio Della Sala, Francesco De Riccardis, Chiara Costabile, Irene Izzo   +6 more
wiley   +1 more source