Results 31 to 40 of about 1,739 (160)

Acetoxymaleic Anhydride as Ketene Equivalent in the Diels-Alder Reaction

CHIMIA, 1992
Acetoxymaleic anhydride (AMA) has been shown to be a versatile ketene equivalent in the Diels-Alder reaction for the conversion of 1,3-dienes into cyclohexanones.
Ernest Wenkert, Christian Vial, Ferdinand Näf   +2 more
doaj   +2 more sources

An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring

Advanced Science, EarlyView.
This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal, Kai‐Po Fan, Sheng‐Chun Hung, Jaba Roy Chowdhury, Jun‐Hsun Chung, Meenakshi Ray, Hsiang‐Yun Hsu, Fu‐Cheng Kao, Kuei‐Lin Liu, Zong‐Hong Lin   +9 more
wiley   +1 more source

Hydroxyl-substituted double Schiff-base condensed 4-piperidone/cyclohexanones as potential anticancer agents with biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Novel hydroxyl-substituted double Schiff-base 4-piperidone/cyclohexanone derivatives, 3a–e, 4a–e, 5a–d, and 6a–c, were synthesized and fully characterized by 1H NMR, IR and elemental analysis.
Lianshuang Zhang, Qin Chen, Guige Hou, Wei Zhao, Yun Hou   +4 more
doaj   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis

Chemistry – A European Journal, EarlyView.
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley   +1 more source

Cationic Sulfonium‐Based Tripodal Ligand and Its Rh(I) Complexes

Chemistry – A European Journal, EarlyView.
We report a cationic EP3‐type tripodal ligand based on an aromatic sulfonium cation (E = S+) along with a series of its Rh(I) complexes. Structural, spectroscopic, electrochemical, and computational analyses of these complexes compared to isostructural analogs (E = Si− or P) reveal pronounced electron density depletion at Rh in the sulfonium congener ...
Nitsan Barel, Shrouq Mujahed, Kamal Uddin Ansari, Katarzyna Młodzikowska‐Pieńko, Renana Gershoni‐Poranne, Yuri Tulchinsky   +5 more
wiley   +1 more source

Photolytic Hydrophosphination: Insights Into Catalyzed and Uncatalyzed Processes

Chemistry – A European Journal, EarlyView.
Catalyst‐free photolytic hydrophosphination is demonstrated for vinyl arenes and activated alkenes in polar protic (alcohol) solvents. These reactions appear to be closed‐shell, affirming that even ambient light can impact a reaction—a potentially broad influence on even mundane reactions.
Emma J. Finfer, Evelyn M. Kempf, Rory Waterman   +2 more
wiley   +1 more source

Titanium‐Catalyzed Diastereoselective Keto‐ and Iminonitrile Cyclizations

Chemistry – A European Journal, EarlyView.
The titanium(III)‐catalyzed diastereoselective cyclization of readily‐available substituted ketonitriles gives cyclopentanones in good yield and stereoselectivity. Subsequent 1,2‐addition allows the preparation of cyclopentyls with three consecutive stereocenters.
Christoph Kern, Ritu Singh, Michael A. Unkrig‐Bau, Lukas Jakob, Jan Streuff   +4 more
wiley   +1 more source

Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis

Journal of Enzyme Inhibition and Medicinal Chemistry
The viral genome of the SARS-CoV-2 coronavirus, the aetiologic agent of COVID-19, encodes structural, non-structural, and accessory proteins. Most of these components undergo rapid genetic variations, though to a lesser extent the essential viral ...
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer   +22 more
doaj   +1 more source

Organocatalytic Formal (3+2+1)‐Cycloaddition of Allenoates, Michael Acceptors, and Carbaldehydes

Chemistry – A European Journal, EarlyView.
The use of secondary amine Lewis base organocatalysts allows for the unprecedented activation of allenoates for formal (3+2+1)‐cycloadditions with Michael acceptors and aromatic carbaldehydes. ABSTRACT Employing secondary amines as covalently interacting Lewis basic organocatalysts allows for the activation of electron‐deficient allenes (allenoates ...
David Naderer, Alexander Pötscher, Katharina Eder, Uwe Monkowius, Markus Himmelsbach, Mario Waser   +5 more
wiley   +1 more source