Cyclooxygenase-1 and cyclooxygenase-2 densities measured using positron emission tomography are not altered in the brains of individuals with stable multiple sclerosis. [PDF]
Tang S +11 more
europepmc +1 more source
Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway. [PDF]
Chuang SC +5 more
europepmc +1 more source
Exploring the Anti-inflammatory Potential of Novel Chrysin Derivatives through Cyclooxygenase-2 Inhibition. [PDF]
Lee Y +6 more
europepmc +1 more source
Acquired resistance to jadomycin B in human triple-negative breast cancer cells is associated with increased cyclooxygenase-2 expression. [PDF]
McKeown BT +3 more
europepmc +1 more source
Role of Cyclooxygenase-2 (COX-2) Expression as a Prediction of Persistent Cervical Low Grade Squamous Intraepithelial Lesion (LSIL). [PDF]
Homsup P +3 more
europepmc +1 more source
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Cyclooxygenase-2 and carcinogenesis
Biochimica Et Biophysica Acta: Reviews on Cancer, 2000Numerous investigations have shown that COX-2 is a participant in the pathway of colon carcinogenesis, especially when mutation of the APC tumor suppressor is the initiating event. Moreover, it seems that the amount of COX-2 is important, since there is a correlation between its level of expression and the size of the tumors and their propensity to ...
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Cyclooxygenase-2 and atherosclerosis
Current Opinion in Lipidology, 2002Cyclooxygenase regulates the production of eicosanoids, which modulate physiologic processes in the vessel wall contributing to atherosclerosis and thrombosis, including platelet aggregation, control of vascular tone, and the local inflammatory response.
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Cyclooxygenase 2 and the kidney
Current Opinion in Nephrology and Hypertension, 2001Cyclooxygenase metabolizes arachidonic acid to a family of bioactive fatty acids designated prostaglandins. Two isoforms of cyclooxygenase exist, designated COX1 and COX2. These isoforms are expressed in distinct but important areas of the kidney. COX1 predominates in vascular smooth muscle and collecting ducts, whereas COX2 predominates in the macula ...
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