Results 11 to 20 of about 106,132 (242)

Association between serum prostacyclin and cerebrovascular reactivity in healthy young and older adults

Experimental Physiology, 2023
Platelet activation may contribute to age‐related cerebrovascular dysfunction by interacting with the endothelial cells that regulate the response to vasodilatory stimuli.
Adam T. Corkery, Kathleen B. Miller, Carissa A. Loeper, Laura H. Tetri, Andrew G. Pearson, Nicole A. Loggie, Anna J. Howery, Marlowe W. Eldridge, Jill N. Barnes   +8 more
doaj   +1 more source

Investigation of the «Structure – analgesic activity» Relationship Using Molecular Docking for Cyclooxygenases 1 and 2 in the Series 5-N-arylaminocarbonyl-6-(get)aryl-4-methyl-1,2,3,6-tetrahydropyrimidine-2-thiones

Разработка и регистрация лекарственных средств, 2023
Introduction. Molecular modeling methods are very popular in the scientific community at the present time. The value of the pharmacological action depends on the affinity of the substance to the biological target.
N. A. Buzmakova, K. V. Аndryukov, T. M. Zamaraeva, I. P. Rudakova, K. V. Podchezertseva, A. S. Goman, E. V. Avdeeva, N. V. Slepova, N. V. Dozmorova   +8 more
doaj   +1 more source

Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides

Biomolecules, 2021
Tripterygium wilfordii glycosides (TWG) is a traditional Chinese medicine with effectiveness against rheumatoid arthritis (RA), supported by numerous clinical trials.
Kehong Zhang, Simona Pace, Paul M. Jordan, Lukas K. Peltner, Alexander Weber, Dagmar Fischer, Robert K. Hofstetter, Xinchun Chen, Oliver Werz   +8 more
doaj   +1 more source

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Pharmacology Research & Perspectives, 2021
The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis.
Christopher J. Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Lee Taylor   +3 more
doaj   +1 more source

Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer

Molecular Cancer, 2003
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases.
Adrian Thomas E, Hennig Rene, Ding Xian-Zhong   +2 more
doaj   +1 more source

Phytochemical composition and biological activities of Caryopteris grata and Caryopteris odorata from the Nakyal mountains, Azad Jammu, and Kashmir [PDF]

Archives of Biological Sciences
Medicinal plants Caryopteris grata and Caryopteris odorata from Azad Jammu and Kashmir (AJK), a biodiversity-rich region of the western Himalayas shaped by varied topography and climate, were examined.
Shabbir Mehwash, Ajaib Muhammad, Mazhar Muhammad Waqas, Arooj Zel E., Shabbir Muneeba   +4 more
doaj   +1 more source

Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L.

Biotechnology & Biotechnological Equipment, 2020
In line with the well-established ethnobotanical use of Arum maculatum for the treatment of hemorrhoidal disease, we sought to determine the activities of 30% or 70% ethanol extracts of the plant tubers in an array of pharmacological and biochemical ...
Vladimir Kochmarov, Lyubomir Marinov, Ekaterina Kozuharova, Nadya Hristova-Avakumova, Vera Hadjimitova, Trayko Traykov, Sefedin Biljali, Nexhibe Nuhiu, Niko Benbassat, Georgi Momekov   +9 more
doaj   +1 more source

Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase

Brazilian Journal of Medical and Biological Research, 1999
Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase ...
F.W. Sellke
doaj   +1 more source

Cytosolic phospholipase A2: physiological function and role in disease

Journal of Lipid Research, 2015
The group IV phospholipase A2 (PLA2) family is comprised of six intracellular enzymes (GIVA, -B, -C, -D, -E, and -F) commonly referred to as cytosolic PLA2 (cPLA2)α, -β, -γ, -δ, -ε, and -ζ. They contain a Ser-Asp catalytic dyad and all except cPLA2γ have
Christina C. Leslie
doaj   +1 more source

Major urinary metabolites of 6-keto-prostaglandin F2α in mice[S]

Journal of Lipid Research, 2013
Western diets are enriched in omega-6 vs. omega-3 fatty acids, and a shift in this balance toward omega-3 fatty acids may have health benefits. There is limited information about the catabolism of 3-series prostaglandins (PG) formed from eicosapentaenoic
Dmitry V. Kuklev, Joseph A. Hankin, Charis L. Uhlson, Yu H. Hong, Robert C. Murphy, William L. Smith   +5 more
doaj   +1 more source