Is cyclooxygenase-1 involved in neuroinflammation? [PDF]
J Neurosci Res, 2021 AbstractPurpose: Reactive microglia are an important hallmark of neuroinflammation. Reactive microglia release various inflammatory mediators, such as cytokines, chemokines, and prostaglandins, which are produced by enzymes like cyclooxygenases (COX).
Ghazanfari N +4 more
europepmc +6 more sources
Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. [PDF]
Sci Adv, 2021 Endothelial cyclooxygenase-1–derived prostanoids, including prostacyclin, have clear cardioprotective roles associated with their anti-thrombotic potential but have also been suggested to have paradoxical pathological activities within arteries.
Mitchell JA +9 more
europepmc +4 more sources
Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature [PDF]
Pharmaceuticals, 2018 Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2.
Alessandra Pannunzio, Mauro Coluccia
doaj +3 more sources
Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer [PDF]
JNCI: Journal of the National Cancer Institute, 1998 Numerous studies have demonstrated that the levels of prostaglandins are greater in various cancers, including breast cancer and colon cancer, than in normal tissues. In particular, the inducible form of cyclooxygenase (COX), the rate-limiting enzyme in prostaglandin biosynthesis, is overexpressed in colon tumors.
Daniel Hwang +3 more
semanticscholar +5 more sources
The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation [PDF]
Mediators of Inflammation, 1998 Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo +5 more
doaj +6 more sources
Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues [PDF]
FEBS Letters, 1993 The rate‐limiting step in the formation of prostanoids is the conversion of arachidonic acid to prostaglandin H2 by cyclooxygenase, also known as prostaglandin G/H synthase/cyclooxygenase. Two forms of cyclooxygenase have been characterized: a ubiquitously expressed form (COX‐1) and a recently described second form (COX‐2) inducible by various factors ...
Anthony W. Ford-Hutchinson +1 more
openaire +4 more sources
Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis [PDF]
Journal of Biological Chemistry, 2000 Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE2 biosynthetic pathway. GSH-dependent PGES activity in the cytosol of
Toshihiro Tanioka +4 more
openalex +2 more sources
Mediators of Inflammation, 2014 Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis.
Zsofia Kutil +7 more
doaj +2 more sources
Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer [PDF]
Mediators of Inflammation, 2006 Background and Aims. Arachidonic acid metabolism actively participates in the initiation, climaxing, and resolution phases of inflammation, and its close connection with inflammatory bowel diseases has been only recently discovered.
Yao Mao, Jian'an Ren, Jieshou Li
doaj +7 more sources
Pharmacological analysis of cyclooxygenase-1 in inflammation [PDF]
Proceedings of the National Academy of Sciences, 1998 The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. These lipid mediators play important roles in inflammation and pain and in normal physiological functions.
Jerry Muhammad +9 more
openaire +4 more sources