Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]
Journal of Medicinal Chemistry, 2007 he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P +17 more
core +8 more sources
The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation [PDF]
Mediators of Inflammation, 1998 Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo +5 more
doaj +3 more sources
Is cyclooxygenase-1 involved in neuroinflammation? [PDF]
J Neurosci Res, 2021 Abstract Purpose: Reactive microglia are an important hallmark of neuroinflammation. Reactive microglia release various inflammatory mediators, such as cytokines, chemokines, and prostaglandins, which are produced by enzymes like cyclooxygenases (COX).
Ghazanfari N +4 more
europepmc +4 more sources
Three-dimensional structure of human cyclooxygenase (hCOX)-1
Scientific Reports, 2021 The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurological and ...
Morena Miciaccia +9 more
doaj +1 more source
Interaction of meloxicam and phenylbutazone on the level of cyclooxygenase-2 in mice [PDF]
Iraqi Journal of Veterinary Sciences, 2022 The reason for the recent study was to inspect the therapeutic efficacy of meloxicam and phenylbutazone alone with their analgesic interaction and their subsequent inhibitory interaction at the level of cyclooxygenase-2 in mice.
Yaareb J. Mousa +2 more
doaj +1 more source
Ancient Science of Life, 2018 Background: Agnimantha is a constituent of the bṛhatpañcamūla (the roots drugs of 5 tree species) which in turn is a part of daśamūla used in Ayurvedic pharmaceutical practices.
Narasimha Baba Brindavanam +3 more
doaj +1 more source
Expression and correlation of COX-2 and NUCB1 in colorectal adenocarcinoma [PDF]
PeerJ, 2023 Objective To investigate the expression and correlation of COX-2 and NUCB1 in colorectal adenocarcinoma and adjacent tissues. Methods The expression of COX-2 and NUCB1 and their effects on prognosis were predicted using bioinformatics ...
Yuanyuan Zhang +5 more
doaj +2 more sources
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]
, 2006 Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S. +7 more
core +1 more source
Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer
Mediators of Inflammation, 2006 Background and Aims. Arachidonic acid metabolism actively participates in the initiation, climaxing, and resolution phases of inflammation, and its close connection with inflammatory bowel diseases has been only recently discovered.
Yao Mao, Jian'an Ren, Jieshou Li
doaj +2 more sources
Journal of Applied Oral Science, 2010 Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process.
Ricardo Nogueira Fracon +3 more
doaj +1 more source