Results 11 to 20 of about 23,800,079 (261)

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

FASEB J, 2016
Regular consumption of low‐dose aspirin reduces the occurrence of colorectal, esophageal, stomach, and gastrointestinal cancers. The underlying mechanism is unknown but may be linked to inhibition of angiogenesis.
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD.   +6 more
europepmc   +2 more sources

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system [PDF]

Proceedings of the National Academy of Sciences, 2012
Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production and that this explains the cardiovascular toxicity associated with COX-2 inhibition, yet the evidence for this relies on ...
Malak Al-Yamani, Malak Al-Yamani, Martina H. Lundberg, Martina H. Lundberg, Jane A. Mitchell, P. D. M. Leadbeater, Timothy D. Warner, Nicholas S. Kirkby, Claire M.F. Potter, Ginger L. Milne, Oladipupo Adeyemi, Louise S. Harrington   +11 more
openaire   +5 more sources

Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice. [PDF]

JCI Insight
Embryo implantation is crucial for ensuring a successful pregnancy outcome and subsequent child health. The intrauterine environment during the peri-implantation period shows drastic changes in gene expression and cellular metabolism in response to hormonal stimuli and reciprocal communication with embryos.
Aikawa S, Matsuo M, Akaeda S, Sugimoto Y, Arita M, Isobe Y, Sugiura Y, Taira S, Maeda R, Shimizu-Hirota R, Takeda N, Hiratsuka D, He X, Ishizawa C, Iida R, Fukui Y, Hiraoka T, Harada M, Wada-Hiraike O, Osuga Y, Hirota Y.   +20 more
europepmc   +3 more sources

Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.

Folia Histochemica et Cytobiologica, 2011
Cyclooxigenase (COX) is the rate-limiting enzyme for the conversion of arachidonic acid (AA) to prostaglandins (PGs). Two isoforms of COX have been identified: COX-1 is constitutively expressed in many cells and is involved in cell homeostasis ...
Francesco Burruano, Silvia Tortorici, Angelo Leone, Luana Lipari, Annamaria Mauro, Salvatore Provenzano, Aldo Gerbino, Maria Buscemi   +7 more
doaj   +7 more sources

High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors [PDF]

Carcinogenesis, 2000
Mouse lung tumorigenesis is a convenient model for examining all stages of lung adenocarcinoma (AC) progression. Because enhanced cyclooxygenase 2 (COX-2) expression has been observed in advanced human AC, we investigated the intracellular concentrations of the two cyclooxygenases, cyclooxygenase 1 (COX-1) and COX-2, at different times after carcinogen
Alison K. Bauer, Lori D. Dwyer‐Nield, Alvin M. Malkinson   +2 more
openalex   +4 more sources

Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis [PDF]

Brazilian Journal of Medical and Biological Research, 2007
Ulcerative colitis (UC) is a disease of the colon and rectum characterized by a nonspecific chronic inflammation mediated by the concerted response of cellular and humoral events.
A.P.R. Paiotti, R. Artigiani Neto, N.M. Forones, C.T.F. Oshima, S.J. Miszputen, M. Franco   +5 more
doaj   +7 more sources

Expression of cyclooxygenase-1 and 2 in chronic tonsillitis

Indian Journal of Pathology and Microbiology, 2010
Objectives: Prostaglandins are critical mediators of inflammation and affect both humoral and cell-mediated immune responses. Recent findings show that T and B cells express COX-2 upon activation. The purpose of this study is to investigate the potential
Dilek Fatma, Sahin Onder, Tokyol Cigdem, Mazlum Mustafa, Aycicek Abdullah   +4 more
doaj   +4 more sources

Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers, [PDF]

Biochemistry, 2010
Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2 (also called cyclooxygenases (COXs)-1 and -2) catalyze the committed step in prostaglandin biosynthesis. Both isoforms are targets of nonsteroidal antiinflammatory drugs (NSAIDs). PGHSs are homodimers that exhibit half-of-sites COX activity; moreover, some NSAIDs cause enzyme inhibition by binding
Ranjinder S. Sidhu, William L. Smith, Chong Yuan, Jullia Y. Lee   +3 more
openaire   +4 more sources

The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children [PDF]

BMC Pediatrics
Background Chronic inflammation and its control are crucial to the responses of glomerular and renal tubular cells. This contributes to the pathogenic mechanisms and advancement of the disease in Alport syndrome.
Moushira Zaki, Hisham A. Orban, Mohamed A. Shahba, Rehab S. I. Moustafa, Ahmed Adel, Fatina I. Fadel, Abeer Selim, Hala T. El-Bassyouni, Eman R. Youness   +8 more
doaj   +2 more sources

Platelet inhibition by low-dose aspirin is not influenced by body mass or weight

Platelets, 2022
Aspirin’s clinical efficacy may be influenced by body weight and mass. Although inadequate platelet inhibition by aspirin is suggested as responsible, evidence for this in non-diabetic patients is sparse.
Sean P. Heffron, Joseph Windheim, Tessa J. Barrett, Deepak Voora, Jeffrey S. Berger   +4 more
doaj   +1 more source