Results 221 to 230 of about 106,475 (259)
Some of the next articles are maybe not open access.
Veterinary and Comparative Oncology, 2004
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
K U, Sorenmo +4 more
openaire +2 more sources
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
K U, Sorenmo +4 more
openaire +2 more sources
Brain Research, 1999
Various lines of evidence have implicated inducible cyclooxygenase-2 (COX-2) in fever production. Thus, its expression is selectively enhanced in brain after peripheral exogenous (e.g., lipopolysaccharide [LPS]) or endogenous (e.g., interleukin-1) pyrogen administration, while selective COX-2 inhibitors suppress the fever induced by these pyrogens.
S, Li +5 more
openaire +2 more sources
Various lines of evidence have implicated inducible cyclooxygenase-2 (COX-2) in fever production. Thus, its expression is selectively enhanced in brain after peripheral exogenous (e.g., lipopolysaccharide [LPS]) or endogenous (e.g., interleukin-1) pyrogen administration, while selective COX-2 inhibitors suppress the fever induced by these pyrogens.
S, Li +5 more
openaire +2 more sources
Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
The Histochemical Journal, 1995Prostaglandins are considered to play important roles in gastric mucosal protection. The rate-limiting enzyme involved in the biosynthesis of prostaglandins is cyclooxygenase (COX), also known as prostaglandin H synthase. Two forms of COX are known: a constitutively expressed form (COX-1) and a newly-characterized, inducible form (COX-2).
openaire +2 more sources
Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998Prostacyclin is a key mediator of pulmonary vascular and parenchymal function during late fetal and early postnatal life, and its synthesis in whole lung increases during that period. The rate-limiting enzyme in prostacyclin synthesis in the developing lung is cyclooxygenase (COX).
T S, Brannon +6 more
openaire +2 more sources
Profiling the interaction of 1‐phenylbenzimidazoles to cyclooxygenases
Journal of Molecular Recognition, 2019AbstractIn the design of 1‐phenylbenzimidazoles as model cyclooxygenase (COX) inhibitors, docking to a series of crystallographic COX structures was performed to evaluate their potential for high‐affinity binding and to reproduce the interaction profile of well‐known COX inhibitors. The effect of ligand‐specific induced fit on the calculations was also
Carlos Z. Gómez‐Castro +4 more
openaire +2 more sources
Characteristics of cyclooxygenase-1 and cyclooxygenase-2-deficient mice
1996The prostaglandins (PGs) are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiological processes. Prostaglandin H2 (PGH2) is an obligate intermediate in formation of prostaglandins1, the formation of which from arachidonic acid (AA) is catalysed by prostaglandin H synthase, an enzyme with two known isoforms ...
S. G. Morham, R. Langenbach
openaire +1 more source
Different Methods for Testing Potential Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors
2010The need for the development of selective agents, which only inhibit the mainly "harmful" cyclooxygenase-2 (COX-2) while leaving physiological COX-1 mostly unaffected, still remains, especially after the recent issues related to cardiovascular toxicity caused by some COX-2 selective agents.
Stefan, Laufer, Sabine, Luik
openaire +2 more sources
Cardiovascular Pathology, 2007
Cyclooxygenase is a key enzyme in prostanoid synthesis. It exists in two isoforms: cyclooxygenase-1 (COX-1), which is constitutively expressed in cells and tissues maintaining normal homeostasis, and cyclooxygenase-2 (COX-2), which is normally not present in most cells, but can be induced by various stimuli.
Nina, Zidar +8 more
openaire +2 more sources
Cyclooxygenase is a key enzyme in prostanoid synthesis. It exists in two isoforms: cyclooxygenase-1 (COX-1), which is constitutively expressed in cells and tissues maintaining normal homeostasis, and cyclooxygenase-2 (COX-2), which is normally not present in most cells, but can be induced by various stimuli.
Nina, Zidar +8 more
openaire +2 more sources
Pathobiology, 2004
<i>Objective:</i> COX (cyclooxygenase), a prostaglandin H synthase, catalyzes the rate-limiting step in prostaglandin biosynthesis. Two isoforms of COX have been identified: COX-1 and COX-2. We examined the expression of COX-1 and COX-2 in esophageal normal mucosa, dysplasia and squamous cell carcinoma (SCC). <i>Methods:</i> The
Satoru, Kase +6 more
openaire +2 more sources
<i>Objective:</i> COX (cyclooxygenase), a prostaglandin H synthase, catalyzes the rate-limiting step in prostaglandin biosynthesis. Two isoforms of COX have been identified: COX-1 and COX-2. We examined the expression of COX-1 and COX-2 in esophageal normal mucosa, dysplasia and squamous cell carcinoma (SCC). <i>Methods:</i> The
Satoru, Kase +6 more
openaire +2 more sources
Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps
Journal of Allergy and Clinical Immunology, 2002There is evidence that impairment of prostanoid metabolism might be involved in the pathogenesis of nasal polyps (NPs). Prostanoids are synthesized by 2 cyclooxygenase (Cox) enzymes, one constitutive (Cox-1) and another inducible (Cox-2).The aim of these studies was to investigate Cox-1 and Cox-2 regulation in NPs of aspirin-tolerant human patients ...
Joaquim, Mullol +6 more
openaire +2 more sources