Results 231 to 240 of about 106,475 (259)
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Differential expression of cyclooxygenase-1 and cyclooxygenase-2 in the cornea during wound healing
Tissue and Cell, 2004Cyclooxygenases (COXs) are the key enzymes in the production of prostaglandins (PGs) and exist in two isoforms. Isoform 1 (COX-1) is constitutively expressed in most tissues, whereas cyclooxygenase-2 (COX-2) is rapidly induced by a variety of different stimuli.
Amico C +5 more
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Variants of cyclooxygenase-1 and their roles in medicine
Thrombosis Research, 2003Acetaminophen (paracetamol) and other analgesic/antipyretic drugs such as dipyrone have been postulated to act centrally through inhibition of cyclooxygenases (COXs). COX activity in lipopolysaccharide-stimulated mammalian leukocytes, microglial cells, and platelets is inhibited by these drugs at physiological concentrations.
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The Journal of Pharmacology and Experimental Therapeutics, 1994
Acute inflammatory stimuli elevate both the production of prostaglandins and the synthesis and activity of prostaglandin synthase/cyclooxygenase enzyme (COX) in murine peritoneal macrophages. Adrenalectomy also elevates prostaglandin production, COX synthesis and COX activity in these cells.
J L, Masferrer +6 more
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Acute inflammatory stimuli elevate both the production of prostaglandins and the synthesis and activity of prostaglandin synthase/cyclooxygenase enzyme (COX) in murine peritoneal macrophages. Adrenalectomy also elevates prostaglandin production, COX synthesis and COX activity in these cells.
J L, Masferrer +6 more
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Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Cancer research, 2003Membrane arachidonic acid is converted by cyclooxygenase (COX) into prostaglandin (PG) G(2) and then to PGH(2) which is subsequently metabolized to PGE(2) by PGE synthase (PGES). Both COX-1 and COX-2 play critical roles in intestinal polyp formation, whereas COX-2 is also expressed in cancers of a variety of organs. Likewise, inducible microsomal PGES (
Haruna, Takeda +7 more
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2000
Prostaglandin E2 (PGE2) production in immortalized, non-transformed lung cells derived from wild-type, cyclooxygenase-1 (COX-1)-/- or COX-2-/- defiicient mice was examined after treatment with interleukin-1β (IL-1), tumor necrosis factor α (TNF), acidic fibroblast growth factor (FGF) and phorbol ester (PMA). Compared with their wild-type (COX1+/+/COX-2+
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Prostaglandin E2 (PGE2) production in immortalized, non-transformed lung cells derived from wild-type, cyclooxygenase-1 (COX-1)-/- or COX-2-/- defiicient mice was examined after treatment with interleukin-1β (IL-1), tumor necrosis factor α (TNF), acidic fibroblast growth factor (FGF) and phorbol ester (PMA). Compared with their wild-type (COX1+/+/COX-2+
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Cloning, expression, and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2.
Veterinary therapeutics : research in applied veterinary medicine, 2003Cyclooxygenase (COX) performs the critical initial reaction in the arachidonic metabolic cascade, leading to formation of proinflammatory prostaglandins, thromboxanes, and prostacyclins. The discovery of a second COX isoform (COX-2) associated with inflammation led to agents that selectively inhibit COX-2.
James K, Gierse +7 more
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Expression of cyclooxygenase 1 and cyclooxygenase 2 in the canine testis
Reproductive Biology, 2013D. Rodler, F. Sinowatz
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Regulation of cyclooxygenase activity by metamizol
European Journal of Pharmacology, 1999Federico Gago +2 more
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