Results 231 to 240 of about 23,800,079 (261)
Some of the next articles are maybe not open access.
Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Optic Nerve Head
Experimental Eye Research, 1997To investigate the hypothesis that eicosanoids act as cellular mediators in the optic nerve head of normals and of patients with glaucoma, we have determined the presence of the two cyclooxygenase (COX) isoforms in human tissue. Histological sections of optic nerve heads were studied by immunohistochemistry. Age matched normal donors were compared with
Miriam Gonzalez +3 more
openaire +3 more sources
Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis
JCR: Journal of Clinical Rheumatology, 1998The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
openaire +2 more sources
Brain Research, 1999
Various lines of evidence have implicated inducible cyclooxygenase-2 (COX-2) in fever production. Thus, its expression is selectively enhanced in brain after peripheral exogenous (e.g., lipopolysaccharide [LPS]) or endogenous (e.g., interleukin-1) pyrogen administration, while selective COX-2 inhibitors suppress the fever induced by these pyrogens.
S.G Morham +6 more
openaire +2 more sources
Various lines of evidence have implicated inducible cyclooxygenase-2 (COX-2) in fever production. Thus, its expression is selectively enhanced in brain after peripheral exogenous (e.g., lipopolysaccharide [LPS]) or endogenous (e.g., interleukin-1) pyrogen administration, while selective COX-2 inhibitors suppress the fever induced by these pyrogens.
S.G Morham +6 more
openaire +2 more sources
Characteristics of cyclooxygenase-1 and cyclooxygenase-2-deficient mice
1996The prostaglandins (PGs) are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiological processes. Prostaglandin H2 (PGH2) is an obligate intermediate in formation of prostaglandins1, the formation of which from arachidonic acid (AA) is catalysed by prostaglandin H synthase, an enzyme with two known isoforms ...
S. G. Morham, R. Langenbach
openaire +2 more sources
Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998Prostacyclin is a key mediator of pulmonary vascular and parenchymal function during late fetal and early postnatal life, and its synthesis in whole lung increases during that period. The rate-limiting enzyme in prostacyclin synthesis in the developing lung is cyclooxygenase (COX).
Todd S. Sherman +7 more
openaire +3 more sources
Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
The Histochemical Journal, 1995Prostaglandins are considered to play important roles in gastric mucosal protection. The rate-limiting enzyme involved in the biosynthesis of prostaglandins is cyclooxygenase (COX), also known as prostaglandin H synthase. Two forms of COX are known: a constitutively expressed form (COX-1) and a newly-characterized, inducible form (COX-2).
openaire +3 more sources
Veterinary and Comparative Oncology, 2004
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
Karin U. Sorenmo +4 more
openaire +3 more sources
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
Karin U. Sorenmo +4 more
openaire +3 more sources
Profiling the interaction of 1‐phenylbenzimidazoles to cyclooxygenases
Journal of Molecular Recognition, 2019AbstractIn the design of 1‐phenylbenzimidazoles as model cyclooxygenase (COX) inhibitors, docking to a series of crystallographic COX structures was performed to evaluate their potential for high‐affinity binding and to reproduce the interaction profile of well‐known COX inhibitors. The effect of ligand‐specific induced fit on the calculations was also
Carlos Z. Gómez‐Castro +4 more
openaire +3 more sources
Different Methods for Testing Potential Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors
2010The need for the development of selective agents, which only inhibit the mainly "harmful" cyclooxygenase-2 (COX-2) while leaving physiological COX-1 mostly unaffected, still remains, especially after the recent issues related to cardiovascular toxicity caused by some COX-2 selective agents.
Stefan Laufer, Sabine Luik
openaire +2 more sources
Differential expression of cyclooxygenase-1 and cyclooxygenase-2 in the cornea during wound healing
Tissue and Cell, 2004Cyclooxygenases (COXs) are the key enzymes in the production of prostaglandins (PGs) and exist in two isoforms. Isoform 1 (COX-1) is constitutively expressed in most tissues, whereas cyclooxygenase-2 (COX-2) is rapidly induced by a variety of different stimuli.
Amico C +5 more
openaire +5 more sources