Results 261 to 270 of about 186,613 (302)

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in the human prostate

Urology, 2000
To determine the cell-specific expression of the two major isoforms of cyclooxygenase (COX-1 and COX-2) in human noncancerous and cancerous prostatic tissues.Thirty-one specimens of prostate carcinoma (CaP) and 10 specimens of benign prostatic hyperplasia (BPH) were stained with mouse antihuman COX-1 and COX-2 monoclonal antibodies.
A, Kirschenbaum, A P, Klausner, R, Lee, P, Unger, S, Yao, X H, Liu, A C, Levine   +6 more
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Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Optic Nerve Head

Experimental Eye Research, 1997
To investigate the hypothesis that eicosanoids act as cellular mediators in the optic nerve head of normals and of patients with glaucoma, we have determined the presence of the two cyclooxygenase (COX) isoforms in human tissue. Histological sections of optic nerve heads were studied by immunohistochemistry. Age matched normal donors were compared with
A H, Neufeld, M R, Hernandez, M, Gonzalez, A, Geller   +3 more
openaire   +2 more sources

Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2

2010
Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Nicholas R, Staten, Beverly A, Reitz
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Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis

JCR: Journal of Clinical Rheumatology, 1998
The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
openaire   +2 more sources

Different Methods for Testing Potential Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors

2010
The need for the development of selective agents, which only inhibit the mainly "harmful" cyclooxygenase-2 (COX-2) while leaving physiological COX-1 mostly unaffected, still remains, especially after the recent issues related to cardiovascular toxicity caused by some COX-2 selective agents.
Stefan, Laufer, Sabine, Luik
openaire   +2 more sources

Characteristics of cyclooxygenase-1 and cyclooxygenase-2-deficient mice

1996
The prostaglandins (PGs) are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiological processes. Prostaglandin H2 (PGH2) is an obligate intermediate in formation of prostaglandins1, the formation of which from arachidonic acid (AA) is catalysed by prostaglandin H synthase, an enzyme with two known isoforms ...
S. G. Morham, R. Langenbach
openaire   +1 more source

Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998
Prostacyclin is a key mediator of pulmonary vascular and parenchymal function during late fetal and early postnatal life, and its synthesis in whole lung increases during that period. The rate-limiting enzyme in prostacyclin synthesis in the developing lung is cyclooxygenase (COX).
T S, Brannon, A N, MacRitchie, M A, Jaramillo, T S, Sherman, I S, Yuhanna, L R, Margraf, P W, Shaul   +6 more
openaire   +2 more sources

Caveolin‐1 facilitates cyclooxygenase‐2 protein degradation

Journal of Cellular Biochemistry, 2009
AbstractCyclooxygenase‐2 (COX‐2) plays major roles in diverse physiological and pathological processes such as inflammation and tumorigenesis. Transcriptional control of COX‐2 has been extensively investigated and characterized, but its post‐translational control is less clear. Here, we report a novel mechanism by which COX‐2 is degraded.
Shu-Fen, Chen, Jun-Yang, Liou, Tai-Yu, Huang, Yu-Sin, Lin, Ai-Ling, Yeh, Kabik, Tam, Tsung-Huang, Tsai, Kenneth K, Wu, Song-Kun, Shyue   +8 more
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Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps

Journal of Allergy and Clinical Immunology, 2002
There is evidence that impairment of prostanoid metabolism might be involved in the pathogenesis of nasal polyps (NPs). Prostanoids are synthesized by 2 cyclooxygenase (Cox) enzymes, one constitutive (Cox-1) and another inducible (Cox-2).The aim of these studies was to investigate Cox-1 and Cox-2 regulation in NPs of aspirin-tolerant human patients ...
Joaquim, Mullol, Joan C, Fernàndez-Morata, Jordi, Roca-Ferrer, Laura, Pujols, Antoni, Xaubet, Pedro, Benitez, Cesar, Picado   +6 more
openaire   +2 more sources

Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs

The American Journal of Medicine, 1998
Both isoforms of cyclo-oxygenase, COX-1 and COX-2, are inhibited to varying degrees by all of the available nonsteroidal anti-inflammatory drugs (NSAIDs). Because inhibition of COX-1 by NSAIDs is linked to gastrointestinal ulcer formation, those drugs that selectively inhibit COX-2 may have less gastrointestinal toxicity.
B, Cryer, M, Feldman
openaire   +2 more sources