Results 271 to 280 of about 186,613 (302)
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Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
The Histochemical Journal, 1995Prostaglandins are considered to play important roles in gastric mucosal protection. The rate-limiting enzyme involved in the biosynthesis of prostaglandins is cyclooxygenase (COX), also known as prostaglandin H synthase. Two forms of COX are known: a constitutively expressed form (COX-1) and a newly-characterized, inducible form (COX-2).
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Veterinary and Comparative Oncology, 2004
AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
K U, Sorenmo +4 more
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AbstractProstatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis.
K U, Sorenmo +4 more
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‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors
Bioorganic & Medicinal Chemistry, 2007Resveratrol ((E)-3,4',5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. In order to find more selective COX inhibitors a series of bridged stilbene derivatives was synthesized and evaluated for their ability to inhibit both COX-1 and COX-2 in vitro.
Handler, Norbert +6 more
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Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin, 2015
Fragestellung: Klinisch werden immer wieder die entzundungshemmenden Wirkungen von Torf bei der Behandlung rheumatologischer Erkrankungen beobachtet. Bislang ist aus der Torfforschung nicht klar hervorgegangen, warum ein Moorbreibad antientzundliche Effekte aufweist. Die thermischen Effekte alleine konnen diese Wirkungen nicht erklaren.
A. Beer +3 more
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Fragestellung: Klinisch werden immer wieder die entzundungshemmenden Wirkungen von Torf bei der Behandlung rheumatologischer Erkrankungen beobachtet. Bislang ist aus der Torfforschung nicht klar hervorgegangen, warum ein Moorbreibad antientzundliche Effekte aufweist. Die thermischen Effekte alleine konnen diese Wirkungen nicht erklaren.
A. Beer +3 more
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Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Cancer research, 2003Membrane arachidonic acid is converted by cyclooxygenase (COX) into prostaglandin (PG) G(2) and then to PGH(2) which is subsequently metabolized to PGE(2) by PGE synthase (PGES). Both COX-1 and COX-2 play critical roles in intestinal polyp formation, whereas COX-2 is also expressed in cancers of a variety of organs. Likewise, inducible microsomal PGES (
Haruna, Takeda +7 more
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Cloning, expression, and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2.
Veterinary therapeutics : research in applied veterinary medicine, 2003Cyclooxygenase (COX) performs the critical initial reaction in the arachidonic metabolic cascade, leading to formation of proinflammatory prostaglandins, thromboxanes, and prostacyclins. The discovery of a second COX isoform (COX-2) associated with inflammation led to agents that selectively inhibit COX-2.
James K, Gierse +7 more
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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
Nature Reviews Cancer, 2001Raymond N Dubois
exaly
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
Cell, 2015Santiago Zelenay +2 more
exaly