Results 251 to 260 of about 190,703 (326)

Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1. [PDF]

Cancer Prev Res (Phila), 2017
Lichtenberger LM, Fang D, Bick RJ, Poindexter BJ, Phan T, Bergeron AL, Pradhan S, Dial EJ, Vijayan KV.   +8 more
europepmc   +1 more source

Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents

, 2011
Raju Gautam, Sanjay M. Jachak, Vivek Kumar, C. Gopi Mohan   +3 more
openalex   +1 more source

c-Jun/Activator Protein-1 Mediates Interleukin-1β-induced Dedifferentiation but Not Cyclooxygenase-2 Expression in Articular Chondrocytes [PDF]

, 2005
Sang‐Gu Hwang, Sungsook Yu, Haryoung Poo, Jang‐Soo Chun   +3 more
openalex   +1 more source

[Cyclooxygenase-1 and cyclooxygenase-2--important for the clinicians?].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1998
T K, Kvien, K E, Giercksky, H E, Rugstad
openaire   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Cyclooxygenase-2 Unlike Cyclooxygenase-1 is Highly Expressed in Ovine Embryos during the Implantation Period1 [PDF]

, 1997
Gilles Charpigny, Pierrette Reinaud, Jean-Philippe Tamby, Christophe Créminon, Michel Guillomot   +4 more
openalex   +1 more source

Effect of cyclooxygenase(COX)-1 and −2 expression on VEGF and HGF production in fibroblasts

, 2000
Masahiko Tsujii, Shingo Tsuji, Yutaka Sasaki, Naoki Kawai, Masakazu Yasumaru, Yoshimi Kakiuchi, Arata Kimura, Masatsugu Hori, Sunao Kawano, Raymond N. DuBois   +9 more
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

, 1996
James Otto, William L. Smith
openalex   +1 more source