Results 201 to 210 of about 216,666 (331)

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

, 2009
Gang Yu, Morshed Alam Chowdhury, Khaled R.A. Abdellatif, Ying Dong, Praveen P. N. Rao, Dipankar Das, Carlos Velázquez, Mavanur R. Suresh, Edward E. Knaus   +8 more
openalex   +1 more source

Stereospecificity of Hydrogen Abstraction in the Conversion of Arachidonic Acid to 15R-HETE by Aspirin-treated Cyclooxygenase-2 [PDF]

, 2000
Claus Schneider, Alan Brash
openalex   +1 more source

Cyclooxygenase-1 (COX-1); cyclooxygenase-2 (COX-2) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Immunohistochemical evaluation of cyclooxygenase-2 expression in feline nasal malignant epithelial tumours. [PDF]

J Feline Med Surg
Diop N, Canonne AM, Huet H, Reyes-Gomez E, Béguin J.   +4 more
europepmc   +1 more source

Attenuation of Extracellular Acidic pH-induced Cyclooxygenase-2 Expression by Nitric Oxide

, 2005
Seok Ho, Ji Eun Park, Jin‐Oh Kwak, Hyun‐Woo Kim, Jong Bong Kim, Kwang Youn Lee, Young‐Nam Cha   +6 more
openalex   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis. [PDF]

Ecotoxicol Environ Saf
Zhao L, Wang YF, Adamcakova-Dodd A, Thorne PS, Islam R, Liu KJ, Chen F, Luo J, Liu LZ.   +8 more
europepmc   +1 more source

Cyclooxygenase 2 (COX-2) expression is elevated in prefrontal cortex neurons, not microglia, following methamphetamine self-administration in male and female rats

Amanda M. Acuña, Richard Whittington, Erle E. Peacock, Serena E Rodarte, Jason C. Legg, Erin K. Nagy, A. J. Carlson, Hiba Siddiqui, Julie W Karugu, M. Foster Olive   +9 more
openalex   +2 more sources

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source