Results 351 to 360 of about 21,811,854 (372)
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Cyclooxygenase‐2 and gastric carcinogenesis
APMIS, 2003Epidemiological studies have shown that the use of nonsteroid anti‐inflammatory drugs (NSAIDs) is associated with reduced risk of gastric cancer. The best‐known target of NSAIDs is the cyclooxygenase (Cox) enzyme. Two Cox genes have been cloned, of which Cox‐2 has been connected with gastric carcinogenesis.
J. Jan B. van Lanschot +9 more
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Cyclooxygenase-2 Expression in Chondrosarcoma
Oncology, 2004<i>Objective:</i> In recent years it has become evident that tissue cyclooxygenase-2 (COX-2) may play a role in carcinogenesis and tumor malignancy. There is now a mounting body of information that strongly implies that COX-2 inhibitors may be of some value in the management of patients with carcinomas, and most recently several similar ...
Marianne Wright +4 more
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Cyclooxygenase-2 and Gastrointestinal Cancer
The Cancer Journal, 2004The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin (PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the enzymatic activity of both COX-1 and COX-2. Selective COX-2 inhibitors have been developed that appear to have 50% less gastrointestinal toxicity than traditional nonselective ...
Raymond N. DuBois, Jason R. Mann
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Cyclooxygenase-2 selective inhibitors
Drugs of Today, 1999The identification of two cyclooxygenase (COX) enzymes has been a tremendous advance in understanding the role of prostaglandins in inflammation and the actions of nonsteroidal antiinflammatory drugs (NSAIDs). COX-1 activity appears to be related to "constitutive" or "housekeeping" functions in the gastric mucosa, kidney and platelets.
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Journal of the American Medical Association (JAMA), 2006
CONTEXT Evidence that rofecoxib increases the risk of myocardial infarction has led to scrutiny of other nonsteroidal anti-inflammatory drugs (NSAIDs).
P. McGettigan, D. Henry
semanticscholar +1 more source
CONTEXT Evidence that rofecoxib increases the risk of myocardial infarction has led to scrutiny of other nonsteroidal anti-inflammatory drugs (NSAIDs).
P. McGettigan, D. Henry
semanticscholar +1 more source
Selective inhibition of cyclooxygenase 2
Biochemical Pharmacology, 1994Cyclooxygenase (COX), a key enzyme in the formation of prostanoids, is known to exist in two isoforms: an inducible enzyme (COX 2) and a constitutive from (COX 1). Both enzymes are inhibited by non-steroidal anti-inflammatory drugs (NSAID), but only marginal selectivity has thus far been reported. In this study, we report on a novel selective inhibitor
Volker Ullrich +3 more
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Cyclooxygenase-2: A Therapeutic Target
Annual Review of Medicine, 2002▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2. In many situations, the COX-1 enzyme is produced constitutively (e.g., in gastric mucosa), whereas COX-2 is highly inducible (e.
Raymond N. DuBois, Marco Turini
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[Cyclooxygenase 2 and carcinogenesis].
Bulletin du cancer, 2004The membrane glycoprotein Cox2 is regulated at transcriptional and post-transcriptional levels by pro-inflammatory agents, cytokines, growth factors, oncogenes, and tumor-promoters. Cox2 is expressed during early stages of colorectal carcinogenesis from the premalignant adenoma stage, and adenocarcinomas of stomach, colon, breast, lung and prostate ...
Sylvie, Rodrigues +4 more
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Cyclooxygenase-2 and kidney failure
Prostaglandins & Other Lipid Mediators, 2012Cyclooxygenase (COX)-dependent prostaglandins are necessary for normal kidney function. These prostaglandins are associated with inflammation, maintenance of sodium and water homeostasis, control of renin release, renal vasodilation, vasoconstriction attenuation, and prenatal renal development.
Ana Maria Gámez-Méndez +3 more
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Cyclooxygenase‐2 and Tumor Biology
2007There is now substantial evidence for the role of cyclooxygenase (COX)-2 in causation and prevention of cancer. Selective COX-2 inhibitors (coxibs) were considered attractive candidate chemoprevention agents; however, concerns over the toxicity of systemic selective inhibition have cast some doubt on COX-2 inhibition as a safe chemoprevention strategy.
Shigeru Kanaoka +2 more
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