Results 361 to 370 of about 21,811,854 (372)

Mediation of Inflammation by Cyclooxygenase-2

1995
Non-steroidal antiinflammatory drugs (NSAIDs) are commonly used for the treatment of inflammation, pain, and fever. Mechanistically, these compounds are believed to act via inhibition of the enzyme cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid to the prostaglandins (PGs). Although commercially available NSAIDS are efficacious
Yan Zhang, Karen Seibert, J. Masferrer, Peter C. Isakson, Kathleen M. Leahy, G. Olson, W. E. Perkins, S. Gregory, Stephen L. Hauser   +8 more
openaire   +2 more sources

Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.

Journal of Hepatology, 2019
Yan Chen, Haining Chen, Kui Wang, Lu Zhang, Zhao Huang, Jiayang Liu, Zhe Zhang, Maochao Luo, Yunlong Lei, Yong Peng, Zongguang Zhou, Yuquan Wei, Canhua Huang   +12 more
semanticscholar   +1 more source

Cyclooxygenase-2 and Nitric Oxide

Journal of Cardiovascular Pharmacology, 2006
Nitric oxide (NO) is a simple but pluripotent molecule that is mainly released from vascular endothelial cells where it is formed intracellularly by nitric oxide synthase from L-arginine in response to several stimuli, including shear stress or muscarinic receptor stimulation. NO stimulates guanylyl cyclase to form cyclic guanosine monophosphate, which
openaire   +3 more sources

Cyclooxygenase 2: its regulation, role and impact in airway inflammation

Clinical and Experimental Allergy, 2016
N. N. Rumzhum, A. Ammit
semanticscholar   +1 more source

Cyclooxygenase-2 Inhibitors

Anesthesia & Analgesia, 2003
openaire   +3 more sources

Cyclooxygenase‐2 Regulates NLRP3 Inflammasome‐Derived IL‐1β Production

Journal of Cellular Physiology, 2015
Kuo-Feng Hua, Ju-Ching Chou, S. Ka, Y. Tasi, Ann Chen, Shih-Hsiung Wu, Hsiao-Wen Chiu, Wei-Ting Wong, Yih-Fuh Wang, Change-Ling Tsai, Chen-Lung Ho, Cheng‐Hsiu Lin   +11 more
semanticscholar   +1 more source

Suppression of cyclooxygenase-2

Prostaglandins & Other Lipid Mediators, 1999
Kei Yamamoto, Hiroyasu Tobe, Jining Wang, Show Yamamoto   +3 more
openaire   +2 more sources

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Nature, 1996
R. Kurumbail, A. Stevens, J. Gierse, J. McDonald, R. Stegeman, Jina Y. Pak, Daniel Gildehaus, Julie M. iyashiro, T. Penning, K. Seibert, P. Isakson, W. Stallings   +11 more
semanticscholar   +1 more source

Cyclooxygenase-2 in Lung Cancer

2003
Jenny T. Mao, Steven M. Dubinett, Mariam Dohadwala, Sherven Sharma, Min Huang, Mehis Põld   +5 more
openaire   +3 more sources

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Nature Reviews. Cancer, 2001
Rajnish A. Gupta, R. Dubois
semanticscholar   +1 more source