Results 61 to 70 of about 200,309 (203)

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Carlsson, Maria, Gidlöf, Anders, Sirsjö, Allan, Söderkvist, Peter, Uhl, Eberhard, Öst, Martin   +5 more
core   +1 more source

The Molecular Perspective: Cyclooxygenase-2 [PDF]

The Oncologist, 2000
Imagine preventing cancer before it even starts. Of course, cancer prevention starts at home. We can stay away from smoke, solvents, and sunlight, avoiding unnecessary risks to our cells. We can also eat healthy foods like fruits and vegetables that are filled with protective antioxidants and cleansing fiber.
openaire   +3 more sources

Significance of cyclooxygenase-2 in oncogenesis

Journal of Veterinary Research, 2019
The cyclooxygenase-2 (COX-2) enzyme catalyses the first stage of biosynthesis of prostanoids, proteins that are implicated in various physiological and pathological processes in humans and animals.
Szweda Marta, Rychlik Andrzej, Babińska Izabella, Pomianowski Andrzej   +3 more
doaj   +1 more source

Snail Upregulates Transcription of FN, LEF, COX2, and COL1A1 in Hepatocellular Carcinoma: A General Model Established for Snail to Transactivate Mesenchymal Genes

Cells, 2021
SNA is one of the essential EMT transcriptional factors capable of suppressing epithelial maker while upregulating mesenchymal markers. However, the mechanisms for SNA to transactivate mesenchymal markers was not well elucidated.
Tam Minh Ly, Yen-Cheng Chen, Ming-Che Lee, Chi-Tan Hu, Chuan-Chu Cheng, Hsin-Hou Chang, Ren-In You, Wen-Sheng Wu   +7 more
doaj   +1 more source

Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection [PDF]

, 2015
Background: This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, statins, or both drugs to untreated ...
Alessandro, Zucchi, Andrea, Fuschi, Carbone, Antonio, DE NUNZIO, Cosimo, Elisabetta, Costantini, Palleschi, Giovanni, Pastore, ANTONIO LUIGI, Petrozza, Vincenzo, Silvestri, Luigi, Yazan Al, Salhi   +9 more
core   +1 more source

Cyclooxygenase‐2 in oligodendroglial neoplasms [PDF]

Cancer, 2003
AbstractBACKGROUNDAlthough increased expression of cyclooxygenase‐2 (COX‐2) has been described in association with a variety of neoplasms, including tumors of astrocytic derivation, limited data are available on COX‐2 expression in oligodendrogliomas.METHODSThe current study retrospectively reviewed 53 oligodendrogliomas and 7 oligodendroglioma ...
Elias A, Castilla, Richard A, Prayson, Andrew A, Kanner, Lisa A, Rybicki, Raymond R, Tubbs, Michael A, Vogelbaum, Gene H, Barnett   +6 more
openaire   +2 more sources

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. [PDF]

, 2016
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of
Aguado, Andrea, Anant, Shrikant, Blanco, Fernando F., Brody, Jonathan R., Dixon, Dan A., Meisner-Kober, Nicole, Padhye, Subhash, Preet, Ranjan, Stevens, Laura E., Vishwakarma, Vikalp, Vyas, Alok, Weir, Scott J., Xu, Liang   +12 more
core   +2 more sources

Cyclooxygenase-2-mediated DNA Damage [PDF]

Journal of Biological Chemistry, 2005
Rat intestinal epithelial cells that express the cyclooxygenase-2 (COX-2) gene permanently (RIES cells) were used as a model of in vivo oxidative stress. A targeted lipidomics approach showed that 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) was the major hydroxylated non-esterified lipid formed in unstimulated intact cells.
Seon Hwa, Lee, Michelle V, Williams, Raymond N, Dubois, Ian A, Blair   +3 more
openaire   +2 more sources

Value of COX-2 and HER-2 in Judging Condition and Prognosis in Non-Small Cell Lung Cancer Patients

Cancer Biology & Medicine, 2010
OBJECTIVE To investigate the expressions of cyclooxygenase 2 (COX-2) and human epidermal growth factor receptor-2 (HER-2) in non-small cell lung cancer (NSCLC) and their clinical significance in identifying the progression and prognosis of the NSCLC ...
Lei YANG, Jun-guo LU, Qing-he TAN
doaj   +1 more source