Results 131 to 140 of about 1,126,910 (189)

Cyclooxygenase-2 Inhibitors in Glioma Therapy

American Journal of Therapeutics, 2004
The cyclooxygenase enzyme is a prostaglandin synthase that has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Upregulation of the COX-2 isoform in many cancers has led to investigation regarding the potential role of this enzyme in oncogenesis.
Pierre, Giglio, Victor, Levin
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Cyclooxygenase-2 selective inhibitors and the kidney

Current Opinion in Internal Medicine, 2001
Cyclooxygenases (COX) are the target of non-steroidal anti-inflammatory drugs (NSAIDs) which exert their therapeutic effect by blocking COX's capacity to metabolize arachidonate to a series of biologically active fatty acids, designated prostaglandins.
M D, Breyer, C, Hao, Z, Qi
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Enantiospecific, selective cyclooxygenase-2 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2002
Cyclooxygenase inhibition studies with novel indomethacin alkanolamides demonstrate the potential for dramatic differences in inhibitor properties conferred by subtle structural modifications. The transformation of non-selective alpha-(S)-substituted indomethacin ethanolamides to potent, COX-2 selective inhibitors by simple stereocenter inversion ...
Kevin R, Kozak, Jeffery J, Prusakiewicz, Scott W, Rowlinson, Lawrence J, Marnett   +3 more
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Cyclooxygenase-2 Inhibitors in Lung Cancer

Clinical Lung Cancer, 2004
Prostanoids produced by the arachidonic acid pathway play an important role in multiple stages of carcinogenesis and progression of cancer. Cyclooxygenase (COX), which exists in 2 isoforms, is the rate-limiting enzyme in the COX pathway. Cyclooxygenase-1 is constitutively expressed in normal tissues and is essential for several important physiologic ...
Sakkaraiappan, Ramalingam, Chandra P, Belani   +1 more
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Efficacy of cyclooxygenase-2–specific inhibitors

The American Journal of Medicine, 2001
Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The clinical efficacy of NSAIDs is primarily related to the inhibition of COX-2 activity, whereas much of the toxicity, particularly gastrointestinal toxicity, is related to COX-1 inhibition.
G W, Cannon, F C, Breedveld
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Cyclooxygenase-2 inhibitors in colorectal cancer

Seminars in Oncology, 2003
Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key positions in important physiologic processes such as immunity, reproduction, and vascular integrity. Large retrospective and prospective population-based studies have shown that the use of both nonselective, nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors ...
Jan, Stoehlmacher, Heinz-Josef, Lenz
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Cyclooxygenase-2 Inhibitors: A Painful Lesson

Cardiovascular & Hematological Disorders-Drug Targets, 2006
Non-steroidal anti-inflammatory drugs (NSAIDs) represent a clinically important class of agents. NSAIDs are commonly used in treatment of conditions such as headache, fever, inflammation and joint pain. Complications often arise from chronic use of NSAIDs.
Sandhya, Sanghi, Eric J, MacLaughlin, Coty W, Jewell, Sheldon, Chaffer, Peter J, Naus, Linley E, Watson, David E, Dostal   +6 more
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Pyridazinones as selective cyclooxygenase-2 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.
Chun Sing, Li, Christine, Brideau, Chi Chung, Chan, Chantal, Savoie, David, Claveau, Stella, Charleson, Robert, Gordon, Gillian, Greig, Jacques Yves, Gauthier, Cheuk K, Lau, Denis, Riendeau, Michel, Thérien, Elizabeth, Wong, Petpiboon, Prasit   +13 more
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Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors.

Bioorganic & Medicinal Chemistry, 2010
A new series of ketoprofen analogs were synthesized to evaluate their biological activities as selective cyclooxygenase-2 (COX-2) inhibitors. In vitro COX-1 and COX-2 inhibition studies showed that all compounds were potent and selective inhibitors of ...
A. Zarghi, R. Ghodsi
semanticscholar   +1 more source

Cyclooxygenase-2 inhibitors and cardiovascular risk

Current Opinion in Cardiology, 2006
Cyclooxygenase-2 inhibitors, or coxibs, designed to provide comparable pain relief to traditional nonsteroidal anti-inflammatory drugs with reduced risk of gastrointestinal complications, have come under substantial recent scrutiny because of an increased likelihood of adverse cardiovascular events associated with their use.Data concerning the ...
openaire   +2 more sources