Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]
Neuroscience Research 47(2): 245-253 (2003), 2007 Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury.
arxiv
Virtual screening of Microalgal compounds as potential inhibitors of Type 2 Human Transmembrane serine protease (TMPRSS2) [PDF]
arXiv, 2021 More than 198 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported that result in no fewer than 4.2 million deaths globally. The rapid spread of the disease coupled with the lack of specific registered drugs for its treatment pose a great challenge that necessitate the development of therapeutic agents from a ...
arxiv
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]
Journal of Neurochemistry 100(4): 1108-1120 (2007), 2007 Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition of COX-1 with valeryl salicylate (VAS, 12-120 mg/kg) on prostaglandin E2 (PGE2) levels ...
arxiv
Potential of proteasome inhibitors to inhibit cytokine storm in critical stage COVID-19 patients [PDF]
arXiv, 2020 Patients infected with SARS-CoV-2 show a wide spectrum of clinical manifestations ranging from mild febrile illness and cough up to acute respiratory distress syndrome, multiple organ failure and death. Data from patients with severe clinical manifestations compared to patients with mild symptoms indicate that highly dysregulated exuberant inflammatory
arxiv
Prediction of 5-hydroxytryptamine Transporter Inhibitor based on Machine Learning [PDF]
arXiv, 2019 In patients with depression, the use of 5-HT reuptake inhibitors can improve the condition. Topological fingerprints, ECFP4, and molecular descriptors were used. Some SERT and small molecules combined prediction models were established by using 5 machine learning methods. We selected the higher accuracy models(RF, SVM, LR) in five-fold cross-validation
arxiv
A framework for generalized group testing with inhibitors and its potential application in neuroscience [PDF]
arXiv, 2018 The main goal of group testing with inhibitors (GTI) is to efficiently identify a small number of defective items and inhibitor items in a large set of items. A test on a subset of items is positive if the subset satisfies some specific properties. Inhibitor items cancel the effects of defective items, which often make the outcome of a test containing ...
arxiv
Energetic model of tumor growth [PDF]
, 2004 A macroscopic model of the tumor Gompertzian growth is proposed. This approach is based on the energetic balance among the different cell activities, described by methods of statistical mechanics and related to the growth inhibitor factors. The model is successfully applied to the multicellular tumor spheroid data.
arxiv +1 more source
Coronavirus SARS-CoV-2: Analysis of subgenomic mRNA transcription, 3CLpro and PL2pro protease cleavage sites and protein synthesis [PDF]
arXiv, 2020 Coronaviruses have recently caused world-wide severe outbreaks: SARS (Severe Acute Respiratory Syndrome) in 2002 and MERS (Middle-East Respiratory Syndrome) in 2012. At the end of 2019, a new coronavirus outbreak appeared in Wuhan (China) seafood market as first focus of infection, becoming a pandemics in 2020, spreading mainly into Europe and Asia ...
arxiv
Non-Adaptive Group Testing with Inhibitors [PDF]
arXiv, 2014 Group testing with inhibitors (GTI) introduced by Farach at al. is studied in this paper. There are three types of items, $d$ defectives, $r$ inhibitors and $n-d-r$ normal items in a population of $n$ items. The presence of any inhibitor in a test can prevent the expression of a defective. For this model, we propose a probabilistic non-adaptive pooling
arxiv
Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity. [PDF]
Drug Des Devel Ther, 2023 Ren G +9 more
europepmc +1 more source