Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors [PDF]
Molecules, 2019 Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in ...
Aurora Molinari +7 more
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Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity [PDF]
Drug Design, Development and Therapy, 2023 Guojin Ren,1,* Qili Zhang,1,2,* Pengfei Xia,1– 4 Jie Wang,1 Pengxia Fang,1 Xiaojie Jin,1 Xuejing Peng,1– 4 Yanli Xu,1,5 Jian Zhang,1– 4 Lei Zhao1– 5 1Gansu University of Chinese Medicine, Lanzhou, 730000, People’s Republic of China; 2Northwest ...
Ren G +9 more
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Safety and potential efficacy of cyclooxygenase‐2 inhibitors in coronavirus disease 2019 [PDF]
Clinical & Translational Immunology, 2020 Objectives While the safety of non‐steroidal anti‐inflammatory drugs in COVID‐19 has been questioned, they may be beneficial given the hyper‐inflammatory immune response associated with severe disease. We aimed to assess the safety and potential efficacy
Sean Wei Xiang Ong +8 more
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Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors [PDF]
Molecules, 2000 Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID).
Hosahalli S. Subramanya +5 more
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Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach [PDF]
Pharmaceuticals, 2020 The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was selected as a pivot molecule to perform virtual ligand-based screening from
Rozires P. Leão +9 more
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In situ click chemistry generation of cyclooxygenase-2 inhibitors [PDF]
Nature Communications, 2017 Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory ...
Atul Bhardwaj +3 more
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Clinical Profile of Cyclooxygenase-2 Inhibitors in Treating Non-Small Cell Lung Cancer: A Meta-Analysis of Nine Randomized Clinical Trials. [PDF]
PLoS ONE, 2016 BackgroundEvidence on the benefits of combining cyclooxygenase-2 inhibitor (COX-2) in treating non-small cell lung cancer (NSCLC) is still controversial.
Yuan Yuan Zhou +3 more
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Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma. [PDF]
PLoS ONE, 2016 BACKGROUND:Selective cyclooxygenase-2 (COX-2) inhibitors are analgesic, antipyretic, and anti-inflammatory drugs. They have been found to inhibit the development of glioma in laboratory investigations.
Corinna Seliger +6 more
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Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I) [PDF]
JNCI Journal of the National Cancer Institute, 1998 The rate-limiting enzyme in arachidonate metabolism is mediated by enzymes known as cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H2, the precursor of molecules, such as prostaglandins, prostacyclin, and thromboxanes.
Makoto M. Taketo
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Clinical experience with cyclooxygenase‐2 inhibitors [PDF]
Rheumatology, 2002 Rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic conditions requiring long-term therapy for pain relief. Currently prescribed non-steroidal anti-inflammatory drugs (NSAIDs) provide symptomatic efficacy, but are frequently associated with gastrointestinal (GI) toxicities such as dyspepsia and ulcerations.
Ángel Lanas
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