Results 31 to 40 of about 1,126,910 (189)

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases.

Current Medicinal Chemistry, 2018
Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies.
M. Ferrer, Carla Busquests-Cortes, X. Capó, S. Tejada, J. Tur, A. Pons, A. Sureda   +6 more
semanticscholar   +1 more source

Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome

Molecules, 2019
Prostaglandins and inhibitors of their synthesis (cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs) were shown to play a significant role in the regulation of hematopoiesis. Partly due to their hematopoiesis-modulating effects, both
Michal Hofer, Zuzana Hoferová, Martin Falk   +2 more
doaj   +1 more source

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation

Mediators of Inflammation, 1998
Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo, L. J. Damore, J. E. Mazuski, G. S. Smith, N. Panesar, D. L. Kaminski   +5 more
doaj   +1 more source

Clinical experience with cyclooxygenase-2 inhibitors [PDF]

Rheumatology, 2002
Rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic conditions requiring long-term therapy for pain relief. Currently prescribed non-steroidal anti-inflammatory drugs (NSAIDs) provide symptomatic efficacy, but are frequently associated with gastrointestinal (GI) toxicities such as dyspepsia and ulcerations.
openaire   +2 more sources

Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats.

PLoS ONE, 2019
Nonsteroidal anti-inflammatory drugs and acetaminophen are cyclooxygenase inhibitors commonly used as symptomatic medicines for myofascial pain syndrome.
Tetsuhiro Shimodaira, Shigeo Mikoshiba, Toru Taguchi   +2 more
doaj   +1 more source

In vitro and In Silico Studies on Curcumin and Its Analogues as Dual Inhibitors for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2)

Journal of Mathematical and Fundamental Sciences, 2013
Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Curcuma longa L. (turmeric). This anti-inflammatory activity was associated with the ability of this compound to inhibit the activity of both cyclooxygenase-1 (COX-1)
Nunung Yuniarti, Perdana Adhi Nugroho, Aditya Asyhar, Sardjiman Sardjiman, Zullies Ikawati, Enade Perdana Istyastono   +5 more
doaj   +1 more source

Individualized ibuprofen treatment using serial B-type natriuretic peptide measurement for symptomatic patent ductus arteriosus in very preterm infants [PDF]

Korean Journal of Pediatrics, 2017
PurposePlasma level of B-type natriuretic peptide (BNP), an emerging, sensitive, and specific biomarker of hemodynamically significant patent ductus arteriosus (PDA), rapidly decreases in infants receiving cyclooxygenase inhibitors for ductal closure. We
Jeonghee Shin, Eun Hee Lee, Jee Hyun Lee, Byung Min Choi, Young Sook Hong   +4 more
doaj   +1 more source

Reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitors

BMC Cancer, 2006
BackgroundEpidemiologic and laboratory investigations suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against breast cancer due to their activity against cyclooxygenase-2 (COX-2), the rate-limiting enzyme of the ...
Randall Harris, Joanne Beebe-Donk, G. Alshafie   +2 more
semanticscholar   +1 more source

Comparison of the clinical efficacy of celebrex and celecoxib for pain relief after periodontal surgeries

Journal of Craniomaxillofacial Research, 2019
Background: Currently one of the most common problems in dentistry is effective pain management after dental surgeries. Celecoxib is the only specific COX-2 inhibitor used in Iran.
Mohammad Reza Naseh, Masoumeh Mirkeshavarz, Zahra Jafary   +2 more
doaj   +1 more source

Subcutaneous emphysema of the face in Sina hospital: A case report

Journal of Craniomaxillofacial Research, 2019
Subcutaneous emphysema of the face is an uncommon complication caused by dental procedures such as curettage, root canal treatment, extraction, restorative treatment and dental instruments like air-water syringe and hand piece.
Farnoosh Mohammadi, Bahman Seraj, Sajjad Baber   +2 more
doaj   +1 more source