Results 31 to 40 of about 58,086 (152)

Cardiovascular risk and inhibition of cyclooxygenase: traditional nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors

Italian Journal of Medicine, 2013
BACKGROUND The development of non-selective nonsteroidal anti-inflammatory drugs (tNSAIDs) and, more recently, of selective inhibitors of the cycloooxygenase-2 isoform (COXIBs), has contributed greatly towards the effective management of patients with ...
M. Campanini, G. Mathieu
doaj   +1 more source

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Acta Pharmaceutica Sinica B, 2022
Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the ...
Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen-Er Chen   +5 more
doaj   +1 more source

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Frontiers in Psychiatry, 2019
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi, Nieves Gómez-Coronado, Adam J. Walker, Oliver D’Arcy Robertson, Oliver D’Arcy Robertson, Bruno Agustini, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Seetal Dodd, Seetal Dodd, Seetal Dodd, Seetal Dodd   +14 more
doaj   +1 more source

Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors

Molecules, 2000
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID).
Hosahalli S. Subramanya, Jagarlapudi A. R. P. Sarma, Dayam Raveendra, Ram K. R. Jetti, Bulusu Gopalakrishnan, Gautam R. Desiraju   +5 more
doaj   +1 more source

m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity

Molecules, 2023
Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role of cyclooxygenase-1 (COX-1) inhibition has been rather neglected.
Damiano Rocchi, Juan F. González, Olmo Martín-Cámara, Maria Grazia Perrone, Morena Miciaccia, Antonio Scilimati, Celine Decouty-Pérez, Esther Parada, Javier Egea, J. Carlos Menéndez   +9 more
doaj   +1 more source

VIRTUAL SCREENING CAMPAIGNS ON ISOFLAVONES TO DISCOVER POTENT CYCLOOXYGENASE-2 INHIBITORS

Jurnal Farmasi Sains dan Komunitas, 2017
By employing recently published structure-based virtual screening (SBVS) to identify potent cyclooxygenase-2 (COX-2) inhibitors, all isoflavones collected by ZINC15 database were virtually screened. There were 3371 isoflavones in ZINC15 database and 1356
Enade Perdana Istyastono
doaj   +1 more source

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: POSSIBILITIES OF REDUCING BACK PAIN INTENSITY IN PATIENTS WITHOSTEOPOROSIS

Современная ревматология, 2009
Objective: to evaluate the efficiency and tolerability of a 10-day course of therapy with different doses of meloxicam in patients with osteoporosis and back pain. Subjects and methods.
N V Toroptsova, T A Korotkova, O A Nikitinskaya   +2 more
doaj   +1 more source

Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line

Journal of Pharmacopuncture, 2017
Objectives: Study of the mechanisms involved in cancer progression suggests that cyclooxygenase enzymes play an important role in the induction of inflammation, tumor formation, and metastasis of cancer cells.
Pouran Makhdoumi, Afshin Zarghi, Bahram Daraei, Gholamreza Karimi   +3 more
doaj   +1 more source

Clinical Profile of Cyclooxygenase-2 Inhibitors in Treating Non-Small Cell Lung Cancer: A Meta-Analysis of Nine Randomized Clinical Trials.

PLoS ONE, 2016
BackgroundEvidence on the benefits of combining cyclooxygenase-2 inhibitor (COX-2) in treating non-small cell lung cancer (NSCLC) is still controversial.
Yuan Yuan Zhou, Zhi Gang Hu, Fan Jun Zeng, Jiao Han   +3 more
doaj   +1 more source

COX-2 in Cancer: Gordian knot or Achilles heel?

Frontiers in Pharmacology, 2013
The networks of blood and lymphatic vessels and of the extracellular matrix and their cellular and structural components, that are collectively termed the tumor microenvironment, are frequently co-opted and shaped by cancer cells to survive, invade and ...
Ioannis eStasinopoulos, Tariq eShah, Marie-France ePenet, Balaji eKrishnamachary, Zaver M. Bhujwalla   +4 more
doaj   +1 more source