Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity [PDF]
Drug Design, Development and Therapy, 2023 Guojin Ren,1,* Qili Zhang,1,2,* Pengfei Xia,1– 4 Jie Wang,1 Pengxia Fang,1 Xiaojie Jin,1 Xuejing Peng,1– 4 Yanli Xu,1,5 Jian Zhang,1– 4 Lei Zhao1– 5 1Gansu University of Chinese Medicine, Lanzhou, 730000, People’s Republic of China; 2Northwest ...
Ren G +9 more
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Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors [PDF]
Molecules, 2019 Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in ...
Aurora Molinari +7 more
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Safety of Cyclooxygenase-2 Inhibitors in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis [PDF]
Drugs Aging, 2019 ObjectiveOur aim was to assess the safety of cyclooxygenase-2 (COX-2) inhibitors in the management of osteoarthritis (OA) in a systematic review and meta-analysis of randomized, placebo-controlled trials.MethodsA comprehensive literature search was ...
E. Curtis +13 more
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Safety and potential efficacy of cyclooxygenase‐2 inhibitors in coronavirus disease 2019 [PDF]
Clinical & Translational Immunology, 2020 Objectives While the safety of non‐steroidal anti‐inflammatory drugs in COVID‐19 has been questioned, they may be beneficial given the hyper‐inflammatory immune response associated with severe disease. We aimed to assess the safety and potential efficacy
Sean Wei Xiang Ong +8 more
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Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma. [PDF]
PLoS ONE, 2016 BACKGROUND:Selective cyclooxygenase-2 (COX-2) inhibitors are analgesic, antipyretic, and anti-inflammatory drugs. They have been found to inhibit the development of glioma in laboratory investigations.
Corinna Seliger +6 more
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Cyclooxygenase-2 Inhibitors [PDF]
Anesthesia & Analgesia, 2003 Background and Summary— Selective cyclooxygenase (COX)-2 inhibitors are increasingly being used in place of “conventional” nonsteroidal anti-inflammatory drugs (NSAIDs). This is because they are just as effective as NSAIDs in relieving arthritic pain and yet less gastrotoxic.
Kristi W, Kelley, Leigh Ann, Ramsey
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Cardiovascular effects of cyclooxygenase‐2 inhibitors: a mechanistic and clinical perspective [PDF]
Br J Clin Pharmacol, 2016 C. Patrono
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The overexpression of COX 2 in Wilms’ tumor [PDF]
Reviews in Clinical Medicine, 2014 Cyclooxygenase 2 has become an important pharmacological target in anticancer therapy due to the over expression of COX 2 in pathological conditions. Wilms’ tumor is a common kidney cancer in children which has shown an increase in COX 2 enzyme level ...
Sara Hashemi
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Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features [PDF]
Türk Patoloji Dergisi, 2017 Objective: Colorectal carcinoma is the most common neoplasm of the gastrointestinal tract. COX-2 expression is upregulated in colorectal carcinoma. Therefore its assessment would identify patients amenable to adjuvant anticyclooxygenase therapy.
Sandhya VENKATACHALA, Manjula RAJENDRAN
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Update on Cyclooxygenase-2 Inhibitors [PDF]
Clinical Journal of the American Society of Nephrology, 2006 Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Cyclooxygenase-2 (COX-2) inhibitors were initially touted as a therapeutic strategy to avoid not only the gastrointestinal but also the renal and cardiovascular side ...
Raymond C, Harris, Matthew D, Breyer
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