Results 11 to 20 of about 24,904,492 (241)

Cyclooxygenase-2 inhibitors: promise or peril?

Mediators of Inflammation, 2002
The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized ...
Laurel J. Mengle-Gaw, Benjamin D. Schwartz   +1 more
doaj   +2 more sources

Efficacy and safety of cyclooxygenase 2 inhibitors for desmoid tumor management: a systematic review. [PDF]

Nagoya J Med Sci, 2021
The efficacy and safety of cyclooxygenase 2 (COX2) inhibitors for the treatment of desmoid-type fibromatosis (DF) are unclear. Therefore, we systematically reviewed related literature to assess the efficacy and safety of COX2 inhibitors for DF treatment.
Emori M, Matsumoto Y, Murahashi Y, Yoshida M, Nishida Y.   +4 more
europepmc   +2 more sources

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Frontiers in Psychiatry, 2019
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi, Nieves Gómez-Coronado, Adam J. Walker, Oliver D’Arcy Robertson, Oliver D’Arcy Robertson, Bruno Agustini, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Seetal Dodd, Seetal Dodd, Seetal Dodd, Seetal Dodd   +14 more
doaj   +2 more sources

Editorial: Risk of cardiovascular events and cyclooxygenase-2 inhibitors ||FREE PAPER||

Vascular Health and Risk Management, 2006
Reza TabrizchiDivision of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John’s, NL, CanadaSelective cyclooxygenase-2 (Cox-2) inhibitors have been at the centre of public attention since the revelation that the
Reza Tabrizchi
doaj   +1 more source

Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials [PDF]

, 2023
Renal colic is an irritating condition that develops after obstruction of the ureter. Selective cyclooxygenase-2 inhibitors are types of non-steroidal anti-inflammatory drugs (NSAIDs) that have beneficial role in treatment various diseases.
Mohammadian Amiri, Mehdi, Darvishi, Mohammad, Demin Al-Khafaji, Ali Hussein, Abosaooda, Munther, Emadichashmi, Sepidehalsadat, Hameed Fayyadh, Shaimaa, Romero Parra, Rosario Mireya   +6 more
core   +1 more source

Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats

Journal of Applied Oral Science, 2010
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process.
Ricardo Nogueira Fracon, Juliana Mazzonetto Teófilo, Izabela Cristina Moris, Teresa Lamano   +3 more
doaj   +1 more source

Microwave-assisted synthesis of a series of 4,5-dihydro-1H-pyrazoles endowed with selective COX-1 inhibitory potency [PDF]

Journal of the Serbian Chemical Society, 2023
Considerable efforts have been directed towards the discovery of selective cyclooxygenase isoxyme 1 (COX-1) inhibitors due to the recent work highlighting the involvement of COX-1 in the pathogenesis of pain, neuroinflammation, cancer and cardiovascular ...
Altintop Mehlika Dilek, Temel Halide Edip, Özdemir Ahmet   +2 more
doaj   +1 more source

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Sohn, Hae-Young, Klauss, V., Schiele, T. M., Krotz, F.   +3 more
core   +1 more source

Computational bioprospecting of andrographolide derivatives as potent cyclooxygenase-2 inhibitors

Biomedical and Biotechnology Research Journal, 2021
Background: Inflammation is a protective response of the human body that still causes a high level of discomfort because of the associated pain and other inflammatory reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs) have certain associated severe
Somdutt Mujwar
doaj   +1 more source

Cyclooxygenase 2 (COX-2) inhibitors

, 2022
Ciklooksigenaza-2 (engl. Cyclooxygenase-2, COX-2) je enzim koji se pojavljuje u bolnim i upaljenim tkivima, dok je u zdravim tkivima uglavnom neaktivan.
Magić, Dina
core   +2 more sources