Results 41 to 50 of about 58,086 (152)

Role of cyclooxygenase-2 in colorectal cancer

Frontiers in Bioscience-Landmark, 2020
Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the major molecules that is involved in the development and progression of colorectal ...
Neha Nanda, Devinder K Dhawan
doaj   +1 more source

Cyclooxygenase-2 Inhibitors in Gynecologic Practice [PDF]

Clinical Medicine & Research, 2003
Treatment of pain and inflammation associated with dysmenorrhea, endometriosis, ovarian cancers and operative procedures is an ongoing challenge in gynecology. Understanding the roles of prostanoids and estrogen in these conditions and appropriate treatment approaches have advanced beyond traditional nonsteroidal anti-inflammatory drugs.
openaire   +2 more sources

gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

BMC Chemistry, 2019
Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.
Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade, Aida Habib   +11 more
doaj   +1 more source

A phase Ⅱ clinical trial of celecoxib combined with platinum-based chemotherapy in the treatment of patients with advanced NSCLC as first-line treatment

Chinese Journal of Lung Cancer, 2008
Background and objective Currently, platinum-based regimes are standard first-line chemotherapy for non-small cell lung cancer. The aim of this study is to evaluate the efficacy, influencing factors and adverse events of celecoxib plus platinum-based ...
Zhijie WANG, Jianchun DUAN, Qingzhi GUO, Zhigang WEI, Weicheng XUE, Meina WU, Jun ZHAO, Lu YANG, Tongtong AN, Xuyi LIU, Jie WANG   +10 more
doaj  

Proteinase-Activated Receptor-2–Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3–Kinase / Akt / Nuclear Factor-κB Pathway in Human Alveolar Epithelial Cells

Journal of Pharmacological Sciences, 2009
Proteinase-activated receptor-2 (PAR2) triggers upregulation of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) formation in human alveolar epithelial A549 cells.
Kazumi Moriyuki, Fumiko Sekiguchi, Kaori Matsubara, Hiroyuki Nishikawa, Atsufumi Kawabata   +4 more
doaj   +1 more source

REVIEW ARTICLE – Intravenous paracetamol in pediatrics: A global perspective

Anaesthesia, Pain & Intensive Care, 2012
Intravenous (IV) Paracetamol is an excellent post operative analgesic and antipyretic in children. Efficacy and tolerability of IV Propacetamol have been established in pediatric practice.
Muzammil Irshad, MBBS, Mehjabeen Malik, MBBS, Aamir Furqan, MBBS   +2 more
doaj  

Specific cyclooxygenase-2 (COX-2) inhibitors [PDF]

Journal of Osteopathic Medicine, 1999
Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently among the most widely prescribed drugs worldwide. Their therapeutic benefits and their side effects in the gastrointestinal tract and kidney, as well as in hemostasis, are of great importance in modem medicine.
openaire   +2 more sources

Demonstration of Antiallodynic Effects of the Cyclooxygenase-2 Inhibitor Meloxicam on Established Diabetic Neuropathic Pain in Mice

Journal of Pharmacological Sciences, 2009
.: Only a few experimental studies have demonstrated the effectiveness of some cyclooxygenase-2 (COX-2) inhibitors for neuropathic pain in diabetic animals.
Satoko Kimura, Hitoshi Kontani
doaj   +1 more source

Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part II) [PDF]

JNCI Journal of the National Cancer Institute, 1998
The rate-limiting enzyme in arachidonate metabolism is mediated by enzymes known as cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H2, the precursor of molecules, such as prostaglandins, prostacyclin, and thromboxanes.
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The Efficacy of Cyclooxygenase-2 Inhibitors for the Male Treatment of Lower Urinary Tract Symptoms: A Systematic Review and Meta-Analysis. [PDF]

Am J Mens Health, 2023
Tang G, Liu M, Ding G, Liu S, Chu Y, Cui Y, Wu J.   +6 more
europepmc   +1 more source