Results 51 to 60 of about 106,395 (322)

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Frontiers in Psychiatry, 2019
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi, Nieves Gómez-Coronado, Adam J. Walker, Oliver D’Arcy Robertson, Oliver D’Arcy Robertson, Bruno Agustini, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Seetal Dodd, Seetal Dodd, Seetal Dodd, Seetal Dodd   +14 more
doaj   +1 more source

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Acta Pharmaceutica Sinica B, 2022
Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the ...
Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen-Er Chen   +5 more
doaj   +1 more source

A structure-based drug design approach for the identification of novel selective Cyclooxygenase-2 inhibitors using resveratrol analogues as lead molecules [PDF]

, 2015
Therapeutic areas for selective cyclooxygenase-2 inhibitors include inflammatory conditions and cancer. A study has demonstrated that hydroxylated analogues of resveratrol, which is found in red wine, inhibit cyclooxygenase-2 selectively.
Caruana, Clarissa, Shoemake, Claire
core  

Evaluation of a Bayesian inference network for ligand-based virtual screening [PDF]

, 2009
Background Bayesian inference networks enable the computation of the probability that an event will occur. They have been used previously to rank textual documents in order of decreasing relevance to a user-defined query. Here, we modify the approach to
A Abdo, A Bender, AG Maldonado, AN Jain, AR Leach, AR Leach, Beining Chen, Christoph Mueller, CX Zhai, D Metzler, EJ Gardiner, EM Voorhees, G Salton, GW Bemis, H Eckert, H Turtle, J Bajorath, J Hert, J Hert, J-F Truchon, JA Grant, JD Holliday, JP Callan, JP Callan, JR Fischer, K Spärck Jones, K Spärck Jones, N Nikolova, P Prathipati, P Willett, P Willett, P Willett, P Willett, P Willett, Peter Willett, RC Glen, RD Brown, RP Sheridan, RP Sheridan, S Siegel, SJ Edgar, T Lengauer, T Strohman, TI Oprea, WR Greiff, X Chen   +45 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity

Molecules, 2023
Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role of cyclooxygenase-1 (COX-1) inhibition has been rather neglected.
Damiano Rocchi, Juan F. González, Olmo Martín-Cámara, Maria Grazia Perrone, Morena Miciaccia, Antonio Scilimati, Celine Decouty-Pérez, Esther Parada, Javier Egea, J. Carlos Menéndez   +9 more
doaj   +1 more source

Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice [PDF]

, 2020
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on ...
Claro Cala, Carmen María, Herrera González, María Dolores, Miñano Sánchez, Francisco Javier, Pérez Montero , Marta, Quintela, José Carlos, Rodríguez Rodríguez , Rosalía, Álvarez de Sotomayor Paz, María   +6 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

VIRTUAL SCREENING CAMPAIGNS ON ISOFLAVONES TO DISCOVER POTENT CYCLOOXYGENASE-2 INHIBITORS

Jurnal Farmasi Sains dan Komunitas, 2017
By employing recently published structure-based virtual screening (SBVS) to identify potent cyclooxygenase-2 (COX-2) inhibitors, all isoflavones collected by ZINC15 database were virtually screened. There were 3371 isoflavones in ZINC15 database and 1356
Enade Perdana Istyastono
doaj   +1 more source