Stimulatory Action of Cyclooxygenase Inhibitors on Hematopoiesis: A Review [PDF]
Molecules, 2012 The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis.
Lenka Weiterová +4 more
doaj +3 more sources
Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. [PDF]
Commun Biol, 2019 Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health emergency and host-directed therapy ...
Mortensen R +9 more
europepmc +2 more sources
Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies. [PDF]
Molecules, 2018 A new series of 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N′-[(E)-(substituted phenyl) methylidene] acetohydrazide derivatives (S1–S18) were synthesized and evaluated for their anti-inflammatory activity, analgesic activity, ulcerogenic activity, lipid ...
Bhat MA +6 more
europepmc +2 more sources
Cyclooxygenase-2 inhibitors: promise or peril? [PDF]
Mediators of Inflammation, 2002 The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized ...
Laurel J. Mengle-Gaw +1 more
doaj +4 more sources
Cyclooxygenase (COX) Inhibitors and the Newborn Kidney [PDF]
Pharmaceuticals, 2012 This review summarizes our current understanding of the role of cyclo-oxygenase inhibitors (COXI) in influencing the structural development as well as the function of the developing kidney.
Wei Qi +3 more
doaj +4 more sources
Frontiers in Psychiatry, 2019 Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi +14 more
doaj +2 more sources
Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling. [PDF]
J Cheminform, 2015 Cyclooxygenases (COX) are present in the body in two isoforms, namely: COX-1, constitutively expressed, and COX-2, induced in physiopathological conditions such as cancer or chronic inflammation.
Cortes-Ciriano I +4 more
europepmc +2 more sources
Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy [PDF]
Frontiers in Immunology, 2021 Chimeric antigen receptor T (CAR-T) cells targeting CD19 came into clinical practice for the treatment of B cell lymphoma in 2018. However, patients being treated for B cell lymphoma often suffer from comorbidities such as chronic pain, cardiovascular ...
Mingya Yang +24 more
doaj +2 more sources
Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors [PDF]
Molecules, 2000 Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID).
Hosahalli S. Subramanya +5 more
doaj +2 more sources
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Nature Communications, 2017 Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory ...
Atul Bhardwaj +3 more
doaj +2 more sources