Results 211 to 220 of about 101,527 (239)

The classification of cyclooxygenase inhibitors.

The Journal of rheumatology, 1998
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Lipsky, P.E., Abramson, S.B., Crofford, L.J., Dubois, R.N., Simon, L.S., Putte, L.B.A. van de   +5 more
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Thalidomide and its analogues as cyclooxygenase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2002
Thalidomide showed cyclooxygenase (COX)-1/2 inhibitory activity with a potency comparable to that of aspirin. Structural development studies of thalidomide resulted in potent COX-1/2 inhibitors, and COX-1-selective and COX-2-selective inhibitors.
Rumiko Shimazawa, Kazuo Nagasawa, Tomomi Noguchi, Yuichi Hashimoto   +3 more
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Rofecoxib: A specific cyclooxygenase inhibitor

Drugs of Today, 2000
Rofecoxib is a new specific cyclooxygenase-2 inhibitor. The efficacy of rofecoxib has been established in the treatment of osteoarthritis, rheumatoid arthritis and acute pain. Rofecoxib has been approved in the United States for the treatment of osteoarthritis and acute pain. Endoscopically proven gastrointestinal ulceration is much less with rofecoxib
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Cyclooxygenase-2 Inhibitors in Lung Cancer

Clinical Lung Cancer, 2004
Prostanoids produced by the arachidonic acid pathway play an important role in multiple stages of carcinogenesis and progression of cancer. Cyclooxygenase (COX), which exists in 2 isoforms, is the rate-limiting enzyme in the COX pathway. Cyclooxygenase-1 is constitutively expressed in normal tissues and is essential for several important physiologic ...
Sakkaraiappan Ramalingam, Chandra P. Belani   +1 more
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Clinical experience with cyclooxygenase-2 inhibitors

Inflammation Research, 1999
Increasing amounts of experimental and clinical data support the role of selective cyclooxygenase (COX)-2 inhibition in anti-inflammatory processes and the role of COX-1 inhibition in increasing the frequency of side effects. This article reviews the regulation of COX-2 in inflammatory processes based on in vitro and in vivo work.
J. van Ryn, Michel Pairet
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Cyclooxygenase inhibitors

2013
Cyclooxygenase (COX) inhibitors are widely used to relieve musculoskeletal pain. COX inhibitors are a group of heterogenous substances including non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol (acetaminophen). Moreover, various selective cyclooxygenase-2 (COX-2) inhibitors with improved gastrointestinal tolerability as compared with ...
Burkhard Hinz, Kay Brune
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[Pharmacology and classification of cyclooxygenase inhibitors].

Gastroenterologie clinique et biologique, 2004
The discovery of at least two cyclooxygenase (COX) isoenzymes had two major consequences: i) to give a new impetus to the research on lipid metabolism, giving rise to the crystallization of these peculiar membrane enzymes, the characterization of their active sites and their gene regulation, and the identification of new metabolic pathways; ii) the ...
Jouzeau, Jean-Yves, Daouphars, Mikaël, Benani, Alexandre, Netter, Patrick   +3 more
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Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin

New England Journal of Medicine, 2001
Patients with arthritis and vascular disease may receive both low-dose aspirin and other nonsteroidal antiinflammatory drugs. We therefore investigated potential interactions between aspirin and commonly prescribed arthritis therapiesWe administered the following combinations of drugs for six days: aspirin (81 mg every morning) two hours before ...
Susan DeMarco, Barbara Tournier, Garret A. FitzGerald, Andrew J. Cucchiara, Shiv Kapoor, Francesca Catella-Lawson, Sachin N. Vyas, Muredach P. Reilly   +7 more
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Cyclooxygenase-2 Inhibitors: A Painful Lesson

Cardiovascular & Hematological Disorders-Drug Targets, 2006
Non-steroidal anti-inflammatory drugs (NSAIDs) represent a clinically important class of agents. NSAIDs are commonly used in treatment of conditions such as headache, fever, inflammation and joint pain. Complications often arise from chronic use of NSAIDs.
Sheldon Chaffer, David E. Dostal, Peter J. Naus, Sandhya Sanghi, Linley E. Watson, Eric J. MacLaughlin, Coty W. Jewell   +6 more
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Efficacy of cyclooxygenase-2–specific inhibitors

The American Journal of Medicine, 2001
Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The clinical efficacy of NSAIDs is primarily related to the inhibition of COX-2 activity, whereas much of the toxicity, particularly gastrointestinal toxicity, is related to COX-1 inhibition.
Grant W. Cannon, Ferdinand C. Breedveld
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