Results 31 to 40 of about 105,086 (353)
Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors
Molecules, 2019 Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in ...
Aurora Molinari +7 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2023 Effects of multiple-dose regimens (oral, daily, once a day for 15 days) of cyclooxygenase (COX) inhibitors etoricoxib (1 and 10 mg/kg), diclofenac sodium (1 and 5 mg/kg) and their combinations with 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol 25
E. A. Ivanova +3 more
doaj +1 more source
Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells [PDF]
, 2017 Indexación: Web of Science; Scopus.Cyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer ...
Arias, J.I. +3 more
core +1 more source
Frontiers in Neurology, 2018 BackgroundDespite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques.
Caroline Lindblad +7 more
doaj +1 more source
Cardiovascular Effects of the Cyclooxygenase Inhibitors [PDF]
Hypertension, 2007 Cyclooxyenase (COX)-2 selective inhibitors were developed to create a new class of nonsteroidal anti-inflammatory drugs (NSAIDs) with properties similar to those of nonselective NSAIDS but without their potential COX-1–mediated gastrointestinal toxicities.1,2 Studies of the various COX-2 selective inhibitors have shown that they are in fact associated ...
openaire +3 more sources
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]
, 2003 Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic ...
Alvarez, Dalia +3 more
core +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021 Background and Objectives: Surgery via different mechanisms causes immunosuppression in the postoperative period. The aim of the present study was to investigate the effects of preoperative administration of cyclooxygenase inhibitors on blood levels of ...
Mohammad Abyari +4 more
doaj
Impact of cyclooxygenase inhibitors in the Women's Health Initiative hormone trials: secondary analysis of a randomized trial. [PDF]
, 2006 OBJECTIVES: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials.
Choe, John H +11 more
core +3 more sources
Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]
, 2006 Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner +9 more
core +1 more source
Cyclooxygenase Inhibitors Derived from Thalidomide.
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Kazuo Nagasawa +6 more
openaire +4 more sources