Results 31 to 40 of about 2,867,692 (324)

Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature

Pharmaceuticals, 2018
Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2.
A. Pannunzio, M. Coluccia
semanticscholar   +1 more source

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation

Mediators of Inflammation, 1998
Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo, L. J. Damore, J. E. Mazuski, G. S. Smith, N. Panesar, D. L. Kaminski   +5 more
doaj   +1 more source

Cardiovascular Effects of the Cyclooxygenase Inhibitors [PDF]

Hypertension, 2007
Cyclooxyenase (COX)-2 selective inhibitors were developed to create a new class of nonsteroidal anti-inflammatory drugs (NSAIDs) with properties similar to those of nonselective NSAIDS but without their potential COX-1–mediated gastrointestinal toxicities.1,2 Studies of the various COX-2 selective inhibitors have shown that they are in fact associated ...
openaire   +3 more sources

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases.

Current Medicinal Chemistry, 2018
Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies.
M. Ferrer, Carla Busquests-Cortes, X. Capó, S. Tejada, J. Tur, A. Pons, A. Sureda   +6 more
semanticscholar   +1 more source

Cyclooxygenase inhibitors use is associated with reduced risk of esophageal adenocarcinoma in patients with Barrett's esophagus: a meta-analysis

British Journal of Cancer, 2014
Background:Esophageal adenocarcinoma (EAC) has high mortality and is increasing in incidence. Barrett’s esophagus (BE) increases the risk for EAC.
S. Zhang, X-Q Zhang, X. Ding, R. Yang, S.L. Huang, F. Kastelein, M. Bruno, X-J Yu, D. Zhou, X. Zou   +9 more
semanticscholar   +1 more source

Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Journal of Inflammation Research, 2022
Mohamed A Abdelgawad,1 Mohammad M Al-Sanea,1 Arafa Musa,2 Mohammed Elmowafy,3 Ashraf K El-Damasy,4 Amany A Azouz,5 Mohammed M Ghoneim,6 Rania R Bakr7 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf, 72341 ...
Abdelgawad MA, Al-Sanea MM, Musa A, Elmowafy M, El-Damasy AK, Azouz AA, Ghoneim MM, Bakr RR   +7 more
doaj  

Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016).

MedChemComm, 2017
Most drugs used to treat pain and inflammation act through inhibition of the enzymes prostaglandin G/H synthase, commonly known as cyclooxygenase (COX). Among these, the simultaneous inhibition of cyclooxygenase 1 (COX-1) would explain the unwanted side ...
G. Carullo, F. Galligano, F. Aiello
semanticscholar   +1 more source

Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity

Drug Design, Development and Therapy, 2023
Guojin Ren,1,* Qili Zhang,1,2,* Pengfei Xia,1– 4 Jie Wang,1 Pengxia Fang,1 Xiaojie Jin,1 Xuejing Peng,1– 4 Yanli Xu,1,5 Jian Zhang,1– 4 Lei Zhao1– 5 1Gansu University of Chinese Medicine, Lanzhou, 730000, People’s Republic of China; 2Northwest ...
Ren G, Zhang Q, Xia P, Wang J, Fang P, Jin X, Peng X, Xu Y, Zhang J, Zhao L   +9 more
doaj  

Assessment of Platelet Function in Traumatic Brain Injury—A Retrospective Observational Study in the Neuro-Critical Care Setting

Frontiers in Neurology, 2018
BackgroundDespite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques.
Caroline Lindblad, Eric Peter Thelin, Eric Peter Thelin, Michael Nekludov, Arvid Frostell, David W. Nelson, Mikael Svensson, Bo-Michael Bellander   +7 more
doaj   +1 more source

Cyclooxygenase Inhibitors Derived from Thalidomide.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kazuo Nagasawa, Hiroki Kakuta, Aya Tanatani, Yuichi Hashimoto, Yohei Muroya, Mamiko Suizu, Hiroyuki Kagechika   +6 more
openaire   +4 more sources