Results 61 to 70 of about 105,086 (353)

Antiseizure properties of fenamate NSAIDs determined in mature human stem-cell derived neuroglial circuits

Frontiers in Pharmacology
Repeated and uncontrolled seizures in epilepsy result in brain cell loss and neural inflammation. Current anticonvulsants primarily target ion channels and receptors implicated in seizure activity.
Hamed Salmanzadeh, Robert F. Halliwell
doaj   +1 more source

Celecoxib in breast cancer prevention and therapy. [PDF]

, 2018
Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively
Cao, Wei, Hao, Qiongyu, Li, Jieqing, Vadgama, Jaydutt V, Wu, Yong   +4 more
core  

Potential use of COX-2–aromatase inhibitor combinations in breast cancer [PDF]

, 2005
Cyclooxygenase-2 (COX-2) is overexpressed in several epithelial tumours, including breast cancer. Cyclooxygenase-2-positive tumours tend to be larger, higher grade, node-positive and HER-2/neu-positive.
A Ristimaki, AL Hsu, AT Koki, CH Liu, CJ Torrance, CK Osborne, CS Williams, CT Dang, E Half, E Nakata, E Pesenti, FM Giardiello, G Chan, G Davies, G Ferrandina, G Gasparini, G Spizzo, G Steinbach, GP Boland, GP O’Neill, GT O-Donoghue, H Sano, H Sawaoka, HR Herschman, JA Richards, JL Masferrer, JM Woods, K Kirkpatrick, K-B Tan, KM Nicholson, LR Howe, LW Chow, LY Dirix, M Baum, M Dowsett, M Tsujii, MD Michael, MJ Ellis, N J Bundred, N L P Barnes, NK Altorki, ON Tucker, P-H Tan, RK Phillips, RW Brueggemeier, RW Brueggemeier, S Lanza-Jacoby, S Shishodia, SH Chang, SL Fu, T Hla, TK Asano, V Benoit, Y Zhao   +53 more
core   +2 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Effect of paracetamol and celecoxib on the state of hemocoagulation in the most acute period of heat injury in rats

Medičnì Perspektivi
Acute heat injury (AHI) occurs due to exposure to high environmental temperatures and is considered a dangerous condition that requires effective prevention and treatment.
P.O. Chuykova, S.Yu. Shtrygol’, I.O. Lebedynets, D.V. Lytkin   +3 more
doaj   +1 more source

Histomorphological changes in thymus and spleen after cyclooxygenase inhibitors treatment [PDF]

Морфологія, 2009
The influence of cyclooxygenase inhibitors on the lymphoid organs histomorphology has been examined in the matured outbread white mice. Diclofenac, meloxicam, celecoxib, but not rofecoxib has shown depressive action on the im-munocompetetive organs ...
Poeta O.N., Gorbunov A.A., Mamchur V.Yo.
doaj  

Benzophenone Semicarbazones as Potential alpha-glucosidase and Prolyl Endopeptidase Inhibitor: In-vitro free radical scavenging, enzyme inhibition, mechanistic, and molecular docking studies [PDF]

arXiv, 2023
$\alpha$-glucosidase and prolylendopeptidase has altered expression and activity patterns in neurological disease, type 2diabetes respectively and several cancers. Here we screened a series 1-29 benzophenone semicarbazone derivatives for in vitro free radical scavenging, alpha-glucosidase and prolylendopeptidase inhibition activities. Seven derivatives
arxiv  

Predictability of IL-28B-polymorphism on protease-inhibitor-based triple-therapy in chronic HCV-genotype-1 patients: A meta-analysis [PDF]

World Journal of Hepatology, 6(10):759-765, 2014, 2014
AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and pegylated interferon-$\alpha$ (Peg-INF-$\alpha$) based triple-therapy.
arxiv   +1 more source

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source