Results 41 to 50 of about 53,400 (215)

Isoform-Specific Inhibition of Cyclophilins [PDF]

Biochemistry, 2009
Cyclophilins belong to the enzyme class of peptidyl prolyl cis-trans isomerases which catalyze the cis-trans isomerization of prolyl bonds in peptides and proteins in different folding states. Cyclophilins have been shown to be involved in a multitude of cellular functions like cell growth, proliferation, and motility.
Sebastian, Daum, Michael, Schumann, Sebastian, Mathea, Tobias, Aumüller, Molly A, Balsley, Stephanie L, Constant, Boris Féaux, de Lacroix, Fabian, Kruska, Manfred, Braun, Cordelia, Schiene-Fischer   +9 more
openaire   +2 more sources

Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc

Hypertension in Pregnancy, 2017
Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level.
Noroyono Wibowo, Riyan Hari Kurniawan, Rima Irwinda, Natasya Prameswari   +3 more
doaj   +1 more source

FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion [PDF]

, 1993
Using a rat model, the effect of pre-treatment with FK 506 on hepatic ischemia/reperfusion injury was investigated. All control animals died within 72 h of the ischemia/reperfusion injury.
Aarden, Billiau, Camussi, Chollet-Martin, Colletti, Colletti, Craig J. McClain, David H. Van Thiel, Farber, Ferrante, Fischer, Francavilla, Francavilla, Gamble, Gauldie, Giorgio M. Zetti, Hajjar, Harding, Hayashi, Hishinuma, Honchel, Howard, Jirik, Judith S. Gavaler, Kahan, Kahn, Kawakani, Kim, Kim, Kino, Kishimoto, Kishimoto, Kramer, Lotz, Magilavy, Mahmoud F. Sakr, Makowka, Makowka, Matuschak, Maury, Mazzaferro, Meer, Miyahara, Mizel, Nagakawa, Nagakawa, Nawroth, Nordan, Nordan, Pennica, Perez-Tamayo, Pohlman, Sakai, Sakr, Shalaby, Shaw, Siekierka, Starzl, Starzl, Strieter, Takahashi, Thomas E. Starzl, Van Snick, Wankowicz, Yushimira   +64 more
core   +1 more source

Cyclophilin D Modulates Mitochondrial Acetylome [PDF]

Circulation Research, 2013
Rationale: Mice lacking cyclophilin D (CypD −/− ), a mitochondrial chaperone protein, have altered cardiac metabolism. As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic
Tiffany Tuyen M, Nguyen, Renee, Wong, Sara, Menazza, Junhui, Sun, Yong, Chen, Guanghui, Wang, Marjan, Gucek, Charles, Steenbergen, Michael N, Sack, Elizabeth, Murphy   +9 more
openaire   +2 more sources

Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin

Cells, 2021
Impairment of efferocytosis in apoptotic macrophages is a known determinant of the severity of atherosclerosis and the vulnerability of plaques to rupture. The precise mechanisms involved in impaired efferocytosis are unclear.
Vinitha Anandan, Thushara Thulaseedharan, Aishwarya Suresh Kumar, Karthika Chandran Latha, Amjesh Revikumar, Ajit Mullasari, Chandrasekharan C. Kartha, Abdul Jaleel, Surya Ramachandran   +8 more
doaj   +1 more source

An endoplasmic reticulum-specific cyclophilin. [PDF]

Molecular and Cellular Biology, 1991
Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clones representing a ubiquitously expressed mRNA from mice and humans.
K W, Hasel, J R, Glass, M, Godbout, J G, Sutcliffe   +3 more
openaire   +2 more sources

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj   +1 more source

Cyclophilin B serum levels present variations across the menstrual cycle

Scientific Reports, 2023
Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño, Cristina Gil-Mouce, Manuel A. Botana, Sandra Gegunde, Jesús González-Jartín, Mercedes R. Vieytes, Amparo Alfonso, Luis M. Botana   +7 more
doaj   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Carbajo-Lozoya, Javier, Dall'Armi, Ekatarina von, Ditt, Vanessa, Drosten, Christian, Friedel, Caroline C., Haas, Juergen G., Herrler, Georg, Herzog, Petra, Hilgenfeld, Rolf, Kallies, Stefan, Kuri, Thomas, Kögl, Manfred, Müller, Marcel A., Niemeyer, Daniela, Pfefferle, Susanne, Pumpor, Ksenia, Pöhlmann, Stefan, Schwarz, Frank, Schwegmann-Wessels, Christel, Schöpf, Julia, Steffen, Imke, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Thiel, Volker, Weber, Friedemann, Zimmer, Ralf, Züst, Roland   +27 more
core   +1 more source

Cyclophilin D in mitochondrial pathophysiology

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Cyclophilins are a family of peptidyl-prolyl cis-trans isomerases whose enzymatic activity can be inhibited by cyclosporin A. Sixteen cyclophilins have been identified in humans, and cyclophilin D is a unique isoform that is imported into the mitochondrial matrix.
GIORGIO, VALENTINA, SORIANO GARCIA - CUERVA, MARIA EUGENIA, BASSO E, BISETTO E, LIPPE G, FORTE MA, BERNARDI, PAOLO   +6 more
openaire   +7 more sources