Results 11 to 20 of about 17,328 (234)

Functional analysis of leishmania cyclopropane fatty acid synthetase [PDF]

, 2012
The single gene encoding cyclopropane fatty acid synthetase (CFAS) is present in Leishmania infantum, L. mexicana and L. braziliensis but absent from L. major, a causative agent of cutaneous leishmaniasis. In L.
Mottram Jeremy C., Evans, K.J., Samuel O. Oyola (112546), Barbara A. Smith (112553), Smith, Barbara A., Terry K Smith, Smith Barbara A., Samuel O Oyola, Smith, Deborah F., Paul M Kaye, James D. Hilley (112558), Kaye, Paul M., Evans, Krystal J., Smith, Terry K., Smith, B.A., Oyola, Samuel O., Hilley, J.D., Mottram, J.C., Kaye, P.M., Oyola, S.O., Jeremy C. Mottram (112563), Smith Terry K., Terry K. Smith (112550), Smith, D.F., Mottram, Jeremy C., Hilley James D., Oyola Samuel O., Paul M. Kaye (54054), Deborah F. Smith (112029), Krystal J Evans, Evans Krystal J., Jeremy C Mottram, Kaye Paul M., James D Hilley, Smith, T.K., Barbara A Smith, Krystal J. Evans (112547), Smith Deborah F., Deborah F Smith, Hilley, James D.   +39 more
core   +1 more source

Lewis Acid-Mediated Formation of 1,3-Disubstituted Spiro[cyclopropane-1,2′-indanes]: The Activating Effect of the Cyclopropane Walsh Orbital [PDF]

, 2020
By virtue of its alkylidenecyclopropane moiety, 2-(cyclopropylidenemethyl)­benzaldehyde reacts with a range of amines and thiols under Lewis acid catalysis.
Francisco-Jose Ballester (8496750), Pilar Sanchez-Andrada, Marta Marin-Luna, Angel Vidal (2294026), Raul-Angel Orenes (2157052), Raul-Angel Orenes, Juan-Antonio Vivancos, Francisco-Jose Ballester, Mateo Alajarin, Marta Marin-Luna (1774054), Pilar Sanchez-Andrada (2294023), Juan-Antonio Vivancos (8496753), Angel Vidal, Mateo Alajarin (1507981)   +13 more
core   +3 more sources

The Synthesis of Single Enantiomers of α-Mycolic Acids of Mycobacterium­ tuberculosis and Related Organisms, with Alternative­ Cyclopropane Stereochemistries

SynOpen, 2017
We report the synthesis of three stereoisomers of a mycolic acid from Mycobacterium tuberculosis containing a di-cis-cyclopropane and of two stereoisomers of a mycolic acid containing a proximal trans-cyclopropane and a distal cis-cyclopropane.
Chioma Don Lawson, Max Maza-Iglesias, Muthana M. Sirhan, Jumaa R. Al Dulayymi, Mark S. Baird   +4 more
doaj   +1 more source

Recent Developments in Stereoselective Reactions of Sulfonium Ylides

Organics, 2022
This review describes advances in the literature since the mid-1990s in the area of reactions of sulfonium ylide chemistry, with particular attention paid to stereoselective examples.
Mukulesh Mondal, Sophie Connolly, Shi Chen, Shubhanjan Mitra, Nessan J. Kerrigan   +4 more
doaj   +1 more source

How do Cyclopropane Fatty Acids Protect the Cell Membrane of Escherichia coli in Cold Shock?

, 2023
The cyclopropanation of unsaturated lipid acyl chains of some bacterial cell membranes is an important survival strategy to protect the same against drastic cooling.
Archita, Maiti, Snehasis, Daschakraborty, Abhay, Kumar   +2 more
core   +1 more source

Antiviral Cyclopropane Acids from Deep-Sea-Derived Fungus Aspergillus sydowii

Marine Drugs, 2022
Four novel monocyclic cyclopropane acids, namely, sydocyclopropanes A–D (1–4), along with one known congener hamavellone B (5), were isolated from the Aspergillus sydowii MCCC 3A00324 fungus, which was isolated from the deep-sea sediment.
Siwen Niu, Shuhuan Huang, Bihong Hong, Qixi Huang, Xiupian Liu, Zongze Shao, Gaiyun Zhang   +6 more
doaj   +1 more source

Cyclopropane-Derived Peptidomimetics. Design, Synthesis, and Evaluation of Novel Ras Farnesyltransferase Inhibitors

, 2016
Trisubstituted cyclopropanes have previously been established as rigid replacements of dipeptide arrays in several biological systems. Toward further evaluating the utility of these dipeptide mimics in the design of novel CA1A2X-based inhibitors of Ras ...
Michael C. Hillier (2526424), James P. Davidson (1856965), Stephen F. Martin (1338225)   +2 more
core   +2 more sources

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria [PDF]

, 2007
Background. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall.
Robert C Reynolds, Coxon, Geoffrey D., Dover, Lynn, Geoffrey D Coxon, Besra, Gurdyal; id_orcid, Besra, Gurdyal S., Besra, Gurdyal, Dover, Lynn G., Reynolds, Robert C., Laurent Kremer, Trivelli, X, Trivelli, Xavier, James C Sacchettini, Sacchettini, JC, Anuradha Alahari, Lynn G Dover, Kremer, Laurent, Kremer, L, Guérardel, Yann, Dover, Lynn G, Coxon, Geoffrey D, Coxon, GD, Gurdyal S Besra, Sacchettini, James C., Reynolds, Robert, Yann Guérardel, Reynolds, Robert C, Reynolds, RC, Coxon, Geoffrey, Gu��rardel, Yann, Alahari, Anuradha, Sacchettini, James C, Gu rardel, Y, Alahari, A, Besra, Gurdyal S, Xavier Trivelli, El-Shemy, Hany, Sacchettini, James   +37 more
core   +1 more source

3,4,5,6,7,8,9-Heptachlorophenaleno[1,9-bc]pyrazole

Molbank, 2009
Treatment of perchloro-7H-cyclopropano[a]acenaphthylene 1 with hydrazine hydrate in DMF at ca. 80 °C gives the new 3,4,5,6,7,8,9-heptachlorophenaleno[1,9-bc]pyrazole 2 in 69% yield. This compound is the first example of a phenalene fused pyrazole.
Polina K. Demetriadou, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Um estudo teórico de propriedades moleculares em complexos de hidrogênio trimoleculares C2H4···2HF, C2H2···2HF e C3h6···2HF A theoretical study of molecular properties of C2H4···2HF, C2H2···2HF AND C3H6···2HF trimolecular hydrogen-bonded complexes

Química Nova, 2008
We present a theoretical study of molecular properties in C2H4···2HF, C2H2···2HF and C3H6···2HF trimolecular hydrogen-bonded complexes. From B3LYP/6-311++G(d,p) calculations, the most important structural deformations are related to the C=C (C2H4), C ...
Boaz G. Oliveira, Regiane C. M. U. Araújo, Flávia S. Pereira, Emmanuela F. Lima, Washington L. V. Silva, Antônio B. Carvalho, Mozart N. Ramos   +6 more
doaj   +1 more source