Results 31 to 40 of about 17,328 (234)

Cyclopropane-Containing Polyamine Analogues Are Efficient Growth Inhibitors of a Human Prostate Tumor Xenograft in Nude Mice

, 2016
Polyamine analogues 7, 10, 18, 27, and 32 containing cyclopropane rings were obtained by chemical synthesis. Their antineoplastic activities were assessed against the cultured human prostate tumor cell lines DU-145, DuPro, and PC-3.
Yulia Maxuitenko (3016758), Laurence J. Marton (3016752), Andrei V. Blokhin (2283487), Subhra Bhattacharya (3016734), John A. Kink (2266495), Venodhar K. Reddy (3016746), Aldonia Valasinas (3016761), Aparajita Sarkar (3016749), George Wilding (3016743), Benjamin Frydman (3016755), Sara Brummel (3016737), Dawn Church (3016740), Hirak S. Basu (3016764)   +12 more
core   +1 more source

Electrogenerated base-promoted cyclopropanation using alkyl 2-chloroacetates

Beilstein Journal of Organic Chemistry, 2022
The electrochemical reduction conditions of the reaction of alkyl 2-chloroacetates in Bu4NBr/DMF using a divided cell equipped with Pt electrodes to produce the corresponding cyclopropane derivatives in moderate yields were discovered.
Kouichi Matsumoto, Yuta Hayashi, Kengo Hamasaki, Mizuki Matsuse, Hiyono Suzuki, Keiji Nishiwaki, Norihito Kawashita   +6 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Substrate‐Affinitive P‐Type Azapolycyclic Photosensitizer for Chemoselective Nitrilization Under Mild Conditions

Advanced Science, EarlyView.
We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Seongwoo Bae, Dongwook Kim, Jinwoo Kim
wiley   +1 more source

(1aR*,2R*,7S*,7aS*)-rel-3,6-Dimethoxy-2-methyl-1a,2,7,7a-tetrahydro-2,7-epoxy-1H-cyclopropa[b]naphthalene

IUCrData, 2016
In the racemic title compound, C14H16O3, the dihedral angle formed by the mean planes of the cyclopropane and benzene rings is 5.0 (2)°. In the crystal, a pair of weak C—H...O hydrogen bonds connect two molecules related by a twofold rotation axis, thus ...
Alan J. Lough, Emily Carlson, William Tam   +2 more
doaj   +1 more source

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

Beilstein Journal of Organic Chemistry, 2012
Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by ...
Bo Leng, Stephanie Chichetti, Shun Su, Aaron B. Beeler, John A. Porco Jr.   +4 more
doaj   +1 more source

Stabilisierung des Elektronenakzeptors Hexacyanotrimethylencyclopropan—Strukturelle und Photophysikalische Charakterisierung

Angewandte Chemie, EarlyView.
Ein verbessertes Niedertemperatur Syntheseverfahren hat die erste umfassende strukturelle und spektroskopische Charakterisierung von neutralem Hexacyanotrimethylencyclopropan (CN6CP) ermöglicht. Kombinierte IR/Raman‐, UV/Vis und ssNMR‐Analysen liefern tiefere Einblicke in die oxidationszustandsabhängige Ladungsverteilung, die σ‐Aromatizität des ...
Jan P. Soyka, Alok Mahata, Anja Wiesner, Jennifer Hartfiel, Christian E. Halbig, Katharina J. Franke, Ute Resch‐Genger, Biprajit Sarkar, Siegfried Eigler   +8 more
wiley   +1 more source

Insecticidal activity of the pyrethrins and related compounds IV.—Essential features for insecticidal activity in chrysanthemates and related cyclopropane esters

, 1971
A range of 5‐benzyl‐3‐furylmethyl cyclopropane carboxylates and other esters are evaluated against house‐flies, mustard beetles and two mosquito species.
Barlow, F., Elliott, M., Needham, P. H., Wickham, J. C., Hadaway, A. B., Janes, N. F., Farnham, A. W.   +6 more
core   +1 more source

Catalytic Asymmetric Synthesis of gem‐Dicyano‐Spirocyclopropyl Oxindoles by N‐9‐Anth‐PyBidine‐Co(OAc)2: Advantage of Three‐Component Coupling Approach

ChemistryEurope
A chiral N‐9‐Anth‐PyBidine‐Co(OAc)2 complex catalyzed the kinetically controlled asymmetric Michael/alkylation reaction of 3‐chlorooxindoles with alkylidenemalononitriles to give gem‐dicyano‐spirocyclopropyl oxindoles in a highly diastereo‐ and ...
Takaaki Saito, Ren Miyasaka, Kazumasa Kon, Yuri Takagi, Takayoshi Arai   +4 more
doaj   +1 more source

Determination of Cyclopropane Fatty Acids in Food of Animal Origin by 1H NMR

Journal of Analytical Methods in Chemistry, 2018
Cyclopropane fatty acids (CPFAs) are unusual fatty acids of microbial origin, recently detected in milk and dairy products. CPFAs have been demonstrated to be interesting molecular markers for authentication of dairy products obtained without ensiled ...
Veronica Lolli, Angela Marseglia, Gerardo Palla, Emanuela Zanardi, Augusta Caligiani   +4 more
doaj   +1 more source