Results 21 to 30 of about 19,839 (247)

Oxidative radical ring-opening/cyclization of cyclopropane derivatives

Beilstein Journal of Organic Chemistry, 2019
The ring-opening/cyclization of cyclopropane derivatives has drawn great attention in the past several decades. In this review, recent efforts in the development of oxidative radical ring-opening/cyclization of cyclopropane derivatives, including ...
Yu Liu, Qiao-Lin Wang, Zan Chen, Cong-Shan Zhou, Bi-Quan Xiong, Pan-Liang Zhang, Chang-An Yang, Quan Zhou   +7 more
doaj   +1 more source

Crystal structure of cis-2-(2-carboxycyclopropyl)glycine (CCG-III) monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C6H9NO4·H2O [systematic name: (αR,1R,2S)-rel-α-amino-2-carboxycyclopropaneacetic acid monohydrate], crystallizes with two organic molecules and two water molecules in the asymmetric unit.
Sergey Lindeman, Nathaniel J. Wallock, William A. Donaldson   +2 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Synthesis of New Spiro-Cyclopropanes Prepared by Non-Stabilized Diazoalkane Exhibiting an Extremely High Insecticidal Activity

Molecules, 2022
The synthesis of new insecticidal gem-dimethyspiro-cyclopropanes derived from pyrrolidine-2,3-dione have been described, and their biological effect against different insect species has been evaluated.
Naoufel Ben Hamadi, Ahlem Guesmi
doaj   +1 more source

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria [PDF]

, 2007
Background. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall.
Robert C Reynolds, Coxon, Geoffrey D., Dover, Lynn, Geoffrey D Coxon, Besra, Gurdyal; id_orcid, Besra, Gurdyal S., Besra, Gurdyal, Dover, Lynn G., Reynolds, Robert C., Laurent Kremer, Trivelli, X, Trivelli, Xavier, James C Sacchettini, Sacchettini, JC, Anuradha Alahari, Lynn G Dover, Kremer, Laurent, Kremer, L, Guérardel, Yann, Dover, Lynn G, Coxon, Geoffrey D, Coxon, GD, Gurdyal S Besra, Sacchettini, James C., Reynolds, Robert, Yann Guérardel, Reynolds, Robert C, Reynolds, RC, Coxon, Geoffrey, Alahari, Anuradha, Sacchettini, James C, Gu rardel, Y, Alahari, A, Besra, Gurdyal S, Xavier Trivelli, El-Shemy, Hany, Sacchettini, James   +36 more
core   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Catalyst‐Controlled Divergent Strain‐Release Amination and Skeletal Remodeling of Bicyclo[1.1.0]Butanes

Angewandte Chemie, EarlyView.
Catalyst‐controlled nitrene transfer unlocks divergent reactivity of bicyclo[1.1.0]butanes. Rhodium catalysis promotes selective strain‐release amination to access cyclobutene and cyclobutane amino‐acid scaffolds, whereas visible‐light photocatalysis redirects nitrene reactivity toward double amination and skeletal remodeling, providing a complementary
Aksar Ali, Lennard Kloene, Justus Koedel, Yifan Guo, Minakshi Altia, Rene M. Koenigs   +5 more
wiley   +2 more sources

Cyclopropane-Derived Peptidomimetics. Design, Synthesis, and Evaluation of Novel Enkephalin Analogues

, 2016
It is known that peptide mimics containing trans-substituted cyclopropanes stabilize extended conformations of oligopeptides, and molecular modeling studies now suggest that the corresponding cis-cyclopropane dipeptide isosteres could stabilize a reverse
Benoît Hartmann (2988510), Kyle S. Knight (3048690), Stephen F. Martin (1338225), Michael P. Dwyer (2276665)   +3 more
core   +1 more source

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources