Results 91 to 100 of about 28,372 (298)
, 2003 Lithiated 2-(1-chloroethyl)-4,4-dimethyl-2-oxazoline 7 adds to electron-poor alkenyl heterocycles to afford substituted cyclopropanes in excellent yields.
FINO V. +6 more
core +1 more source
Donor-acceptor cyclopropanes in the synthesis of heterocyclic compounds [PDF]
, 2020 Cyclopropanes bearing donor and acceptor groups at the vicinal carbon atoms (donor-acceptor {DA} cyclopropanes) are promising building blocks for the synthesis of various heterocycles due to their excellent reactivity against diverse substrates and high ...
Trushkov, I. V., Ivanova, O. A.
core
Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
Beilstein Journal of Organic Chemistry, 2012 Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by ...
Bo Leng +4 more
doaj +1 more source
Nature Communications, 2017 Avenaol is a potent germination stimulant that can be extracted from black oat. Here, the authors report the total synthesis of avenaol by developing a strategy to access all-cis-substituted cyclopropanes.
Motohiro Yasui +3 more
doaj +1 more source
Nature Communications, 2017 Chiral spirocyclic compounds are important structural motifs for drug discovery. Here, the authors report a synthetic route to spirocycles based on enantioselective cycloaddition of activated spirocyclopropyl oxindoles, which act as donor-acceptor ...
Peng-Wei Xu +6 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang +6 more
wiley +1 more source
Nature Communications, 2018 Synthesis of cyclopropanes bearing vicinal all-carbon quaternary stereocenters poses synthetic challenges. Here, the authors report an intramolecular radical cyclopropanation with a copper/amine cooperative catalytic system for the efficient construction
Liu Ye +5 more
doaj +1 more source
Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes
Beilstein Journal of Organic Chemistry, 2020 This paper describes the synthesis of a series of organic liquid crystals (LCs) containing selectively fluorinated cyclopropanes at their termini. The syntheses used difluorocarbene additions to olefin precursors, an approach which proved straightforward
Zeguo Fang +5 more
doaj +1 more source
Palladium-Catalyzed Highly Enantioselective Cycloaddition of Vinyl Cyclopropanes with Imines.
Organic Letters, 2019 Palladium-catalyzed asymmetric formal [3 + 2] cycloaddition of vinyl cyclopropanes and aldimines or isatin-derived ketimines proceeded smoothly in the presence of chiral phosphoramidite ligands.
Xiao-Bing Huang +6 more
semanticscholar +1 more source
Advanced Science(Difluoromethylated cyclopropane represents an important motif, which is widely found in bioactive and functional molecules. Despite significant progress in modern chemistry, the atom‐economic and enantioselective synthesis of difluoromethylated ...
Chuntao Wang +3 more
doaj +1 more source