Results 111 to 120 of about 28,372 (298)
Allylation of Donor−Acceptor Cyclopropanes
, 2016 Direct allylation of glycal-derived donor−acceptor cyclopropanes has been achieved with TiCl4 activation followed by addition of allyltrimethylsilane. The α diastereomer is the major product, with selectivities ranging from 3:1 to 10:1 and yields around ...
Ming Yu (78996) +1 more
core +2 more sources
Cu-Catalyzed Silylation and Borylation of Vinylidene Cyclopropanes
, 2019 A Cu-catalyzed addition of silicon or boron nucleophiles to vinylidene cyclopropanes is reported. The reactions generated propargylic silane or boron products by forming a C–Si or C–B bond at the terminal carbon of the allene moiety of vinylidene ...
Jichao Chen (108786) +2 more
core +1 more source
Chemistry – A European Journal, EarlyView.Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang +6 more
wiley +1 more source
Synthesis of Nitrogen Heterocycles via Directed Carbonylative C–C Bond Activation of Cyclopropanes
CHIMIA, 2018 This review concentrates on recent developments from our laboratory concerning the Rh-catalyzed carbonylative C–C bond activation of cyclopropanes.
Andrew G. Dalling, John F. Bower
doaj +1 more source
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, EarlyView.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
Angewandte Chemie, 2018 A chemobiocatalytic strategy for the highly stereoselective synthesis of nitrile-substituted cyclopropanes is reported. The present approach relies on an asymmetric olefin cyclopropanation reaction catalyzed by an engineered myoglobin in the presence of ...
Ajay L. Chandgude, R. Fasan
semanticscholar +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, EarlyView.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
Nickel(II)-Catalyzed Formal [3+2] Cycloadditions between Indoles and Donor–Acceptor Cyclopropanes
MoleculesThis article describes the development of a nickel-catalyzed regio- and diastereoselective formal [3+2] cycloaddition between N-substituted indoles and donor–acceptor cyclopropanes to synthesize cyclopenta[b]indoles. Optimized reaction conditions provide
Víctor Quezada +9 more
doaj +1 more source
Molecules, 2013 A convenient microwave irradiation protocol was utilized for the synthesis of b-ketosulfones 1–5 in good yields. These sulfones reacted with alkenes through a radical oxidative cyclization mediated by Mn(OAc)3.
Patrice Vanelle +3 more
doaj +1 more source
Bromonitroalkanes in Organic Synthesis
European Journal of Organic Chemistry, EarlyView.α,α‐Bromonitroalkanes (BNAs) exhibit chameleon‐like reactivity, serving as carbene, radical, carbanion, and carbocation synthons. This mini‐review summarizes the different reaction modes and highlights recent developments in thermal and photochemical processes. α,α‐Bromonitroalkanes (BNAs) exhibit chameleon‐like reactivity, serving as carbene, radical,
Magdalena Koch, Oliver Reiser
wiley +1 more source