A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo [PDF]
, 2013 Whole-cell catalysts for non-natural chemical reactions will open new routes to sustainable production of chemicals. We designed a cytochrome 'P411' with unique serine-heme ligation that catalyzes efficient and selective olefin cyclopropanation in intact
A Vagin +34 more
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Advanced Science, EarlyView.We have developed a Pd‐catalyzed oxidative cyclopropanation of 1,n‐enynes employing cyclic diacyl peroxides as bifunctional reagents that serve as both tether‐tunable oxidants and spatially controlled dicarboxylate anions. ABSTRACT Bicyclo[n.1.0]alkanes are highly valuable scaffolds in drug discovery and synthetic chemistry.
Ting Yuan, Lei Shi
wiley +1 more source
(1RS,3SR)-1-(4-Methylbenzyl)-7-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-4-one
MolbankThe previously unknown cyclopropane spiro-fused with isoxazol-5-one ((1RS,3SR)-1-(4-methylbenzyl)-7-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-4-one) was synthesized from benzylideneisoxazol-5-one in 34% yield via double methylene transfer from diazomethane ...
Gleb D. Titov, Nikolai V. Rostovskii
doaj +1 more source
An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks
SynOpen, 2017 An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation of the corresponding pyrazolylacetonitriles is developed.
Pavel S. Nosik +3 more
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Types and properties of metal-free catalysts for living polymerizations of biomaterials [PDF]
, 2008 Syntéza biokompatibilních a biodegradabilních polyesterů, použitelných převážně v medicíně, využívá pro polymeraci za otevření kruhu katalyzátory na bázi kovu (např. Sn, Al atd.), které se mohou po implantaci deponovat v těle.
Repka, Martin
core
Investigation of the structure and catalytic activity in olefin cyclopropanation of neutral and cationic dicopper complexes of 3,5-bis(pyridinylimino)benzoic acid. [PDF]
, 2012 Three neutral and one cationic copper(I) complexes with 3,5-bis(pyridinylimino)benzoic acid are synthesized and characterized in solution and in the solid state by a variety of spectroscopic techniques and X-ray crystallography.
Akrivos, P. +5 more
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Angewandte Chemie, EarlyView.Ni: neue Lösung für asymmetrische C(sp3)‐H‐Aktivierung. Die stereoselektive Synthese vollständig kohlenstoffsubstituierter quartärer Stereozentren gelingt durch eine enantioselektive C(sp3)‐H‐Arylierung unter Verwendung eines Ni‐Katalysators auf der Basis eines BINOL‐Derivaten.
Erwan Brunard +4 more
wiley +1 more source
Access to cyclopropanes with geminal trifluoromethyl and difluoromethylphosphonate groups
Beilstein Journal of Organic Chemistry, 2023 A synthetic route to the bench-stable fluorinated masked carbene reagent diethyl 2-diazo-1,1,3,3,3-pentafluoropropylphosphonate, bearing a trifluoromethyl and a difluoromethyl group is reported for the first time.
Ita Hajdin +5 more
doaj +1 more source
Synthesis of Cyclopropanes via Organoiron Methodology: Preparation of \u3cem\u3erac\u3c/em\u3e-Dysibetaine Cpa [PDF]
, 2007 The cyclopropane containing betaine, rac-dysibetaine CPa, was prepared from (1-methoxycarbonylpentadienyl)-Fe(CO)2PPh3+ by nucleophilic addition of nitromethane anion followed by oxidatively induced reductive ...
Donaldson, William A. +3 more
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Hydrogenative Cyclopropanation and Hydrogenative Metathesis
, 2019 The unusual geminal hydrogenation of a propargyl alcohol derivative with [CpXRuCl] as the catalyst entails formation of pianostool ruthenium carbenes in the first place; these reactive intermediates can be intercepted with tethered alkenes to give either
Biberger, T. +3 more
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