Results 11 to 20 of about 82,661 (227)
Viruses, 2023 Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cycle ...
Dandan Liu +8 more
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Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities
Biology, 2023 Proline isomerization, the process of interconversion between the cis- and trans-forms of proline, is an important and unique post-translational modification that can affect protein folding and conformations, and ultimately regulate protein functions and
Deepti Gurung +5 more
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A case of long-term tolerance after kidney transplantation
Медицинская иммунология, 2022 We present a case of long-term organ functioning (ca.10 years) after allografting of a cadaveric kidney without usage of immunosuppressing drugs. In 2005, a patient suffering from a hypertensive form of chronic glomerulonephritis, have received an ...
A. A. Korzhenevsky, N. P. Korzhenevskaya
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Clinics in Dermatology, 1989 Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K. +7 more
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Successful treatment of a rare variant of mesangioproliferative glomerulonephritis with IgM deposits with Cyclosporin A [PDF]
Терапевтический архив, 2020 We present a case with a rare variant of glomerulonephritis, IgM nephropathy, which occurs mainly with nephrotic syndrome. The clinical features of this variant of kidney damage are characterized; the pathogenetic and the transformation of this form of ...
Daria V. Gurova +4 more
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Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint ...
J.N. Francischi +2 more
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Cyclosporin a hepatotoxicity in 66 renal allograft recipients [PDF]
, 1981 Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A.
Iwatsuki, S, Klintmalm, GBG, Starzl, TE
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Dermatologica Sinica, 2017 Background: Psoriasis is a chronic inflammatory disease that affects the skin, joints, and cardiovascular system. Although a potential association of end-stage renal disease (ESRD) with psoriasis has been demonstrated in patients, the potential for the ...
Sebastian Yu +4 more
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Binding of Different Cyclosporin Variants to Micelles Evidenced by NMR and MD Simulations
Membranes, 2023 Peptides play a critical role in the life of organisms, performing completely different functions. The biological activity of some peptides, such as cyclosporins, can be determined by the degree of membrane permeability.
Polina P. Kobchikova +2 more
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Biomolecules, 2023 Interferon-induced transmembrane proteins (IFITMs) block the fusion of diverse enveloped viruses, likely through increasing the cell membrane’s rigidity.
David Prikryl +5 more
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