Results 51 to 60 of about 142,539 (313)

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Long-term results of cyclosporine-steroid therapy in 131 non-matched cadaveric renal transplants. [PDF]

, 1987
One-hundred-and-twenty-eight recipients of 131 consecutive, non-matched cadaver renal allografts were treated with cyclosporine and steroids. They have been followed for 4 to 6 yr.
Carpenter, Barbara J, Gordon, Robert D, Hakala, Thomas R, Iwatsuki, Shunzaburo, Rosenthal, J Thomas, Schroter, Gerhard PJ, Starzl, Thomas E, Taylor, Rodney J, Well, Richard   +8 more
core  

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

Protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (AVNRT) by using extracellular field potential recordings of isolated atrioventricular-node of rabbit [PDF]

, 2011
Introduction: Recent studies have shown acute cardioprotective effects of cyclosporine. The aim of the present study was to determine the protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (AVNRT) by using ...
Alizadeh, A.M., Badaghabadi, F., Changizi, S., Khori, V., Moheimani, H.R., Nayebpour, M., Nejad, S.S., Pourabouk, M., Rajaei, M., Yazdi, H.R.   +9 more
core  

Remission of Kimura disease with carotid hypervascularization after cyclosporine treatment [PDF]

, 2020
No abstract ...
Bartolazzi, Armando, Persechino, Flavia, Persechino, Severino, Raffa, Salvatore, Tammaro, Antonella, Torrisi, Maria Rosaria, Valente, Sabatino, Visco, Vincenzo   +7 more
core   +2 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2021
Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side ...
Oki Suwarsa, Fatima Aulia Khairani, Syawalika Ulya Isneny, Erda Avriyanti, Hartati Purbo Dharmadji, Miranti Pangastuti, Endang Sutedja, Hendra Gunawan   +7 more
doaj   +1 more source

Relapses, Comorbidities, and Predictors of Outcome in Anti‐GABAA Receptor Encephalitis

Annals of Neurology, EarlyView.
Objectives To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti‐γ‐aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utility of LIM‐domain‐only‐protein 5 (LMO5) antibodies as tumor markers.
Claudia Papi, Chiara Milano, Laura Marmolejo, Ana Beatriz Serafim, Esther Aguilar, Mar Guasp, Elianet Fonseca, Mateus Mistieri Simabukuro, Raffaele Iorio, Yuki Fukami, Maria Lucia Schmitz Ferreira Santos, Takashi Miwa, Takashi Araga, Yuto Uchida, Masanori Kurihara, Satoshi Okada, Luz Victoria Garcia, Kenichi Kaida, Natalia Spinola Costa da Cunha, Alberto Vogrig, Florian Lamblin, Juna M. de Vries, Livia Almeida Dutra, Romana Höftberger, Maarten J. Titulaer, Jesús Planagumà, Lidia Sabater, Eugenia Martinez‐Hernandez, Thais Armangué, Francesc Graus, Takahiro Iizuka, Josep Dalmau, Marianna Spatola, Anti‐GABAAR encephalitis study group   +33 more
wiley   +1 more source

Significance of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) for the Monitoring of Treatment Response to Cyclosporine in Patients with Psoriasis

Life, 2023
Neutrophil gelatinase-associated lipocalin (NGAL) may promote development of inflammation in psoriasis, whereas proprotein convertase subtilisin/kexin type 9 (PCSK9) may account for dyslipidemia in some psoriatic patients.
Aleksandra Frątczak, Bartosz Miziołek, Agnieszka Łupicka-Słowik, Marcin Sieńczyk, Karina Polak, Beata Bergler-Czop   +5 more
doaj   +1 more source

Experimenteller Nachweis der metallbezogenen Funktion eines Cyanobactins

Angewandte Chemie, EarlyView.
Patellamide (Cyanobactine) werden von einer cyanobakteriellen Spezies in grosser Menge hergestellt. Diese zyklischen Peptide wurden in der Vergangenheit fast ausschliesslich auf ihre cytotoxischen Eigenschaften untersucht. Wir diskutieren neue experimentelle Daten, die auf eine Metallionen‐abhängige biologische Funktion der Patellamide schliessen ...
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source