Results 81 to 90 of about 141,357 (291)

Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies

Clinical Pharmacology: Advances and Applications, 2020
Yan Li,1 Maria Palmisano,1 Duxin Sun,2 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ 07920, USA; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109,
Li Y, Palmisano M, Sun D, Zhou S
doaj  

Ciclosporina: riscos em idade pediátrica.

Acta Médica Portuguesa, 2010
Cyclosporine has been found to be effective and safe in many inflammatory skin disorders such as psoriasis and atopic dermatitis (AD), in adults and in children. Its use in paediatrics is still under scope.
João Antunes, Catarina Gouveia, Maria João Brito   +2 more
doaj   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, EarlyView.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Guideline for the In Vivo Immunomodulatory Activity Test of Polysaccharide Based on Cyclophosphamide‐Induced Mouse Model

Food Safety and Health, EarlyView.
Abstract graph of the in vivo immunomodulatory activity of polysaccharide based on a cyclophosphamide‐induced mouse model. ABSTRACT The immune system serves as the primary defense mechanism against pathogens and plays a vital role in maintaining host homeostasis. In recent years, natural polysaccharides have emerged as promising immunomodulators due to
Wenlei Nie, Xuecong Tong, Qiao Ding, Xiaojun Huang   +3 more
wiley   +1 more source

Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

Journal of Toxicology, 2016
Cyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study
Said Said Elshama, Ayman El-Meghawry EL-Kenawy, Hosam-Eldin Hussein Osman   +2 more
doaj   +1 more source

Efficacy of cyclosporine for the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: Systemic review and meta-analysis

Dermatologica Sinica, 2017
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening reactions, mainly to drug, characterized by epidermal necrosis and mucous membrane ulceration.
Yu-Tsung Chen, Che-Yuan Hsu, Yu-Ning Chien, Woan-Ruoh Lee, Yu-Chen Huang   +4 more
doaj   +1 more source

A prospective randomized trial of FK506-based immunosuppression after renal transplantation [PDF]

, 1995
A group of 204 adult patients was entered into a prospective, randomized trial comparing FK506/pred-nisone with FK506/azathioprine/prednisone after renal transplantation between August 1, 1991 and October 11,1992.
Demetris, AJ, Fung, JJ, Hakala, TR, Irish, W, Jordan, ML, McCauley, J, Mitchell, S, Randhawa, P, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Vivas, C   +12 more
core   +1 more source

Safety and efficacy of sirolimus combined with cyclosporine in primary membranous nephropathy: a randomized controlled trial

BMC Medicine
Background Calcineurin inhibitors, such as cyclosporine, are primary treatments for membranous nephropathy (MN). Optimizing this regimen is crucial to reduce nephrotoxicity and enhance immunological remission.
Fang Wang, Chao Yang, Yue Shu, Cai-xia Lin, Yao Yao, Yue Li, Yi-miao Zhang, Xin Wang, Li-qiang Meng, Xu-yang Cheng, Gang Liu, Ming-hui Zhao, Zhao Cui   +12 more
doaj   +1 more source

Cumulative exposure to tacrolimus is associated with increased risk of malignancy for solid organ transplant recipients

International Journal of Cancer, EarlyView.
What's New? Long‐term immunosuppression in solid organ transplant recipients (SOTRs) is linked to increased cancer risk. Although this risk potentially increases with greater immunosuppressant exposure, the exact dose‐response pattern remains uncertain.
Sergio A. Acuna, Xun Zhao, Maggie Jones‐Carr, Graham Smith, Kyla Naylor, Bima J. Hasjim, Shiyi Chen, An‐Wen Chan, Nancy Baxter, S. Joseph Kim, Mamatha Bhat   +10 more
wiley   +1 more source

Comparison of the cyclosporine variants A and D by NMR spectroscopy

Учёные записки Казанского университета: Серия Естественные науки, 2019
A natural variant of cyclosporine A, cyclosporine D, has been studied using high-resolution NMR spectroscopy in a non-polar solution (chloroform). A complete assignment of the 1H and 13C NMR signals has been made.
P.P. Kobchikova, Yu.O. Zgadzay, S.V. Efimov, V.V. Klochkov   +3 more
doaj   +1 more source