Results 91 to 100 of about 1,823 (213)

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez   +6 more
wiley   +1 more source

Pharmacogenetics of Mycophenolic Acid in Patients of African Descent: Underrepresentation of African Data

open access: yesClinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Mycophenolic acid (MPA) is a potent antiproliferative immunosuppressive agent used to prevent organ transplant rejection and to treat various immune‐mediated diseases. MPA is the active metabolite formed from the biotransformation of the prodrugs mycophenolate mofetil (MMF) or enteric‐coated mycophenolate sodium (EC‐MPS).
Migael Mouton   +7 more
wiley   +1 more source

Tolypocladamides A-G: Cytotoxic Peptaibols from <i>Tolypocladium inflatum</i>. [PDF]

open access: yesJ Nat Prod, 2022
Senadeera SPD   +11 more
europepmc   +1 more source

Sirolimus for Secondary Prevention of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

open access: yesInternational Journal of Dermatology, Volume 65, Issue 5, Page 952-962, May 2026.
Meta‐analysis of randomized controlled trials shows that switching from calcineurin inhibitors (CNI) to sirolimus in kidney transplant recipients (KTRs) with prior cutaneous squamous cell carcinoma (cSCC) reduces secondary cSCC incidence but increases adverse‐event–related treatment discontinuation.
Yannick Foerster   +4 more
wiley   +1 more source

Efficacy and safety of brodalumab in palmoplantar pustulosis: A 68‐week randomized Phase 3 trial

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 887-899, May 2026.
This open‐label study is a continuation of the 16‐week double‐blind, Phase 3 trial assessing the efficacy and safety of brodalumab 210 mg subcutaneously, till a 68‐week extension period. Continued improvement was seen in the PPPASI 50/75/90 responses, PPPSI scores, PGA 0/1 responses and DLQI. Abstract Background The efficacy and safety of brodalumab in
Masamoto Murakami   +6 more
wiley   +1 more source

Interdialytic blood pressure is independent of weight gain and correlated with serum angiotensin II levels in adults

open access: yesPhysiological Reports, Volume 14, Issue 9, May 2026.
Abstract Chronic volume overload is a major risk factor of hypertension and mortality in chronic dialysis patients. However, the mechanisms responsible for hypertension are unclear. We studied 32 patients (age 23–68 years, 19 females) in chronic hemodiafiltration classified by their interdialytic ambulatory blood pressure (idABP, mmHg) in three groups:
Adolfo Diaz   +5 more
wiley   +1 more source

Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1) [PDF]

open access: yes, 2018
The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane protein that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous substrates from the inside of cells to the outside.
Kroetz, Deanna, Pauli-Magnus, Christiane
core  

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