Results 51 to 60 of about 2,768 (247)

Association of autoimmune diseases with biologic agents targeting type 2 immunity: An observational study using a claims database

Rheumatology &Autoimmunity, EarlyView.
This observational study assessed the association between anti‐type 2 biologic agents and the occurrence of autoimmune diseases using a large real‐world claims database. Anti‐IL‐5 and anti‐IgE therapies were associated with an increased occurrence of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE ...
Shoichiro Inokuchi
wiley   +1 more source

Multidrug-resistant Human Sarcoma Cells with a Mutant P-Glycoprotein, Altered Phenotype, and Resistance to Cyclosporins*

Journal of Biological Chemistry, 1997
A variant of the multidrug-resistant human sarcoma cell line Dx5 was derived by co-selection with doxorubicin and the cyclosporin D analogue PSC 833, a potent inhibitor of the multidrug transporter P-glycoprotein.
Gang Chen, G. Duran, K. Steger, Norman J. Lacayo, J. Jaffrézou, C. Dumontet, B. Sikic   +6 more
semanticscholar   +1 more source

Clinical relevance of P-glycoprotein expression in haematological malignancies [PDF]

, 1994
Although, generally speaking, haematological malignancies are chemotherapy-responsive tumours and high remission induction rates are obtained, disease-related death is the rule rather than the exception.
Nooter, K. (Kees), Sonneveld, P. (Pieter)   +1 more
core   +6 more sources

Reactive Infectious Mucocutaneous Eruption (RIME): An Australian Case Series

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Whilst Reactive Infectious Mucocutaneous Eruption (RIME) displays a low mortality rate, the condition results in significant morbidity and resource allocation, including prolonged hospital admission. As such, early diagnosis and optimisation of treatment is imperative.
Hamish Moore, Emma Ryan, Annabel Stevenson   +2 more
wiley   +1 more source

Magneto-electric Nanoparticles to Enable Field-controlled High-Specificity Drug Delivery to Eradicate Ovarian Cancer Cells [PDF]

, 2013
The nanotechnology capable of high-specificity targeted delivery of anti-neoplastic drugs would be a significant breakthrough in Cancer in general and Ovarian Cancer in particular. We addressed this challenge through a new physical concept that exploited
Atluri, Venkata, Guduru, Rakesh, Khizroev, Sakhrat, Liang, Ping, Nair, Madhavan, Runowicz, Carolyn   +5 more
core   +1 more source

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond‐Gignac, the ANIRIDIA‐NET Clinical Guidelines Working Group, Miriam Barbany, Claus Cursiefen, Stefano Ferrari, Francisco Figueiredo, Christina Grupcheva, Jesper Hjortdal, Elke Kreps, Erlend Landsend, Laura Mauring, Hilde Pedersen, Nora Szentmáry, Bogumil Wowra, the Aniridia‐Europa and Geniris Working Group, Sophie Valleix, Juan Álvarez de Toledo, James Lauderdale, Tor Paaske Utheim, Paolo Rama   +26 more
wiley   +1 more source

Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa [PDF]

, 1988
Cyclophilin (cyclosporin A-binding protein) has a dual localization in the mitochondria and in the cytosol of Neurospora crassa. The two forms are encoded by a single gene which is transcribed into mRNAs having different lengths and 5' termini ...
Hartl, Franz-Ulrich, Köhler, Helmut, Neupert, Walter, Nicholson, Donald W., Pfanner, Nikolaus, Tropschug, Maximilian, Wachter, Elmar   +6 more
core  

The Host Immune Response to Tissue-Engineered Organs: Current Problems and Future Directions [PDF]

, 2016
As the global health burden of chronic disease increases, end-stage organ failure has become a costly and intractable problem. De novo organ creation is one of the long-term goals of the medical community.
Birchall, MA, De Coppi, P, Fishman, JM, Wiles, K   +3 more
core   +1 more source

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez, Camila Leiva‐Castro, Ana M. Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López‐Enríquez, Francisca Palomares   +6 more
wiley   +1 more source

Real‐Life Workup of Chronic Hand Eczema Using a Dedicated Case Report Form: A SIDAPA Multicentre Study

Contact Dermatitis, EarlyView.
From January 2024 to May 2025, 207 patients (68.6% females) affected by CHE were enrolled to be clinically and etiologically investigated using a case report form specifically developed. The accurate workup led to clinical and etiological classification of CHE in about 80% of patients, allowing tailored treatment strategies. ABSTRACT Background Chronic
Rosella Gallo, Fabrizio Guarneri, Katharina Hansel, Luca Stingeni, Maddalena Napolitano, Cataldo Patruno, Monica Corazza, Alessandro Borghi, Ilaria Trave, Emanuela Martina, Maria Michela Lauriola, Rosanna Rita Satta, Caterina Foti, Paolo Romita, Roberta Giuffrida, Silvia Mariel Ferrucci, on behalf of SIDAPA CHE Study Group, Gabriele Biondi, Gabriele Casciola, Florenzia Marielli, Roberto Pinto, Ilaria Salvi   +21 more
wiley   +1 more source