Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells [PDF]
, 2018 Summary: Multidrug resistance (MDR) is a major obstacle in cancer therapy. It results from different mechanisms; among them is P-glycoprotein (P-gp)-mediated drug efflux out of cells. The mechanism of action remains elusive.
Günthert, Maja +3 more
core
The role of acquired host immunity in periodontal diseases
Periodontology 2000, EarlyView.Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane +2 more
wiley +1 more source
Lethal and Sublethal Toxicity Assessment of Cyclosporin C (a Fungal Toxin) against Plutella xylostella (L.). [PDF]
Toxins (Basel), 2022 Wu J, Zhang X, Bashir MH, Ali S.
europepmc +1 more source
Burden of Seasonal Human Coronavirus Infections in Hematopoietic Cell Transplant Recipients
Transplant Infectious Disease, EarlyView.In this large study, we demonstrated that a high ISI is independently associated with HCoV LRI in HCT recipients. HCoV LRI was associated with several adverse outcomes such as ICU admission, oxygen requirement, and mortality. The ISI potentially may be used to identify high‐risk HCT recipients with HCoV infections.
Fareed Khawaja +7 more
wiley +1 more source
Pharmacokinetic study of cyclosporin A (Sandimmun) in patients with primary biliary cirrhosis. [PDF]
, 1984 Scott A. Robson +6 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Calciprotein particles (CPPs) are small calcium‐ and phosphate‐containing nanoaggregates associated with the development of vascular disease (CVD) in chronic kidney disease (CKD). Previously, we have shown that CPPs induce endothelial cell (EC) dysfunction, possibly contributing to CVD in CKD, but the underlying molecular ...
Lian Feenstra +9 more
wiley +1 more source
Mechanism of action of Cyclosporin A: inhibition of lymphokine secretion studied with antigen-stimulated T cell hybridomas. [PDF]
, 1984 Yael Kaufmann +3 more
openalex +1 more source
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
The Journal of Physiology, EarlyView.Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich +5 more
wiley +1 more source
Derivatives of cyclosporin compatible with antibody-based assays: I. The generation of [125I]-labeled cyclosporin. [PDF]
, 1985 Walter C. Mahoney, John W. Orf
openalex +1 more source