Results 61 to 70 of about 2,768 (247)

Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins [PDF]

, 2017
Cyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported the in vitro anti-Trypanosoma cruzi activity of H-7-94 and F-7-62 non-immunosuppressive CsA analogues.
BÚA, J., DUBIN, M., FICHERA, L.E., FUCHS, A.G., MORETTI, G., POTENZA, M., RUIZ, A.M., SCABONE, C.M., WENGER, R.O.   +8 more
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Sirolimus for Secondary Prevention of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

International Journal of Dermatology, EarlyView.
Meta‐analysis of randomized controlled trials shows that switching from calcineurin inhibitors (CNI) to sirolimus in kidney transplant recipients (KTRs) with prior cutaneous squamous cell carcinoma (cSCC) reduces secondary cSCC incidence but increases adverse‐event–related treatment discontinuation.
Yannick Foerster, Julia Palaras, Kristine Mayer, Tilo Biedermann, Oana‐Diana Persa   +4 more
wiley   +1 more source

Efficacy and safety of brodalumab in palmoplantar pustulosis: A 68‐week randomized Phase 3 trial

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This open‐label study is a continuation of the 16‐week double‐blind, Phase 3 trial assessing the efficacy and safety of brodalumab 210 mg subcutaneously, till a 68‐week extension period. Continued improvement was seen in the PPPASI 50/75/90 responses, PPPSI scores, PGA 0/1 responses and DLQI. Abstract Background The efficacy and safety of brodalumab in
Masamoto Murakami, Yukari Okubo, Satomi Kobayashi, Natsuko Kikuta, Yoshiumi Ouchi, Kenta Shishido, Tadashi Terui   +6 more
wiley   +1 more source

Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins. [PDF]

, 2014
Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types.
Adjeroh, Donald, Jiang, Bing-Hua, Jiang, Yue, Lin, Jie   +3 more
core   +3 more sources

Polyomanephropathie nach Nierentransplantation [PDF]

, 2018
Zusammenfassung: Die Polyomanephropathie (BKV-Nephropathie) ist eine bekannte Komplikation nach Organtransplantation. Sie tritt interessanterweise nur nach Nierentransplantation auf und führt zu einer Funktionsverschlechterung bis hin zum ...
Steiger, J.U.
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Engineering and Applications of fungal laccases for organic synthesis [PDF]

, 2008
Laccases are multi-copper containing oxidases (EC 1.10.3.2), widely distributed in fungi, higher plants and bacteria. Laccase catalyses the oxidation of phenols, polyphenols and anilines by one-electron abstraction, with the concomitant reduction of ...
Ballesteros Antonio, Plou Francisco J, García-Burgos Carlos, Camarero Susana, Kunamneni Adinarayana, Alcalde Miguel   +5 more
core   +2 more sources

Peri‐Implant Soft‐Tissue Phenotype Modification for Refractory Peri‐Implant Mucositis: A 12‐Month Prospective Clinical Study With Ultrasonographic Analysis

Journal of Periodontal Research, EarlyView.
Surgical treatment of refractory peri‐implant mucositis with a free gingival graft (FGG) was effective in disease resolution, achieving reductions in probing pocket depth (PPD) and inflammation. Significant gains in mucosal thickness (MT) and keratinized mucosa width (KMW), as well as partial recession coverage and re‐establishment of attached mucosa ...
Shayan Barootchi, Lorenzo Tavelli, Hamoun Sabri, Hom‐Lay Wang, Erfan Barootchi, Mario Romandini, Istvan A. Urban, Zoltan Barath   +7 more
wiley   +1 more source

Clinical management and outcomes for 51 Pugs reportedly diagnosed with protein‐losing enteropathy using VetCompass primary care veterinary data

Journal of Small Animal Practice, EarlyView.
Objectives To report the clinicopathological findings, treatment and outcomes of Pugs diagnosed with protein‐losing enteropathy using VetCompass primary care clinical data in the UK and to determine if referral or any specific treatments for protein‐losing enteropathy were associated with outcome. Materials and Methods Retrospective VetCompass study of
A. Kathrani, D. C. Brodbelt, D. B. Church, D. G. O’Neill   +3 more
wiley   +1 more source

Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet, Clément Pruvot, Zoé Manssens, Wadih Abou‐Chahla, Sébastien Buche   +4 more
wiley   +1 more source

SMB Operation for Three-Fraction Separations: Purification of Plasmid DNA [PDF]

, 2018
The Simulated Moving Bed technology is extended to incorporate a cleaning in place step, and it is then applied by exploiting size exclusion chromatography to purify plasmid DNA.
Makart, Stefan, Mazzotti, Marco, Morbidelli, Massimo, Paredes, Galatea, Stadler, Joachim   +4 more
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