Results 71 to 80 of about 14,435 (202)

Preventive effects of Cyclosporin on diabetes in NOD mice [PDF]

open access: bronze, 1986
Yuki Mori   +11 more
openalex   +1 more source

A Brief Molecular History of Vγ9Vδ2 TCR‐Mediated Phosphoantigen Sensing

open access: yesImmunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Vγ9Vδ2 T‐cells are universally present in humans and represent one of the most prevalent TCR reactivities, evolutionarily conserved across diverse mammalian species. They are an innate‐like subset featuring a semi‐invariant TCR repertoire that drives their well‐recognized reactivity to small, non‐peptidic phosphoantigens (pAg). Crucially, they
Fiyaz Mohammed   +2 more
wiley   +1 more source

Management of Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Patient With Topical Cidofovir and Oral Leflunomide

open access: yesPediatric Transplantation, Volume 29, Issue 3, May 2025.
ABSTRACT Background This case report describes a 10‐year‐old male with a history of kidney transplantation who developed trichodysplasia spinulosa (TS), a rare skin disorder associated with immunosuppression. Methods The patient's condition, characterized by follicular papules and keratinous spines primarily on the face, was managed by a ...
Annika M. Hansen   +4 more
wiley   +1 more source

Elderly Patients With Aplastic Anemia: Treatment Patterns and Outcomes in the Real World

open access: yesAmerican Journal of Hematology, Volume 100, Issue 4, Page 584-591, April 2025.
ABSTRACT We retrospectively analyzed a large international cohort of 1113 patients with aplastic anemia to evaluate treatment choice and outcome in elderly patients as compared with a younger population. Overall, 319 (29%) patients were > 60 years old at diagnosis (60–64 years (n = 85), 106 65–69 years (n = 106), and 128 > 70 years (n = 128)).
Bruno Fattizzo   +15 more
wiley   +1 more source

Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum. [PDF]

open access: yesJ Nat Prod, 2022
Senadeera SPD   +11 more
europepmc   +1 more source

Hailey‐Hailey Disease: A Case Report

open access: yesClinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Hailey‐Hailey disease should be considered in patients with recurrent, painful, pruritic, vesicular lesions in flexural areas. Early diagnosis through histopathology and immunofluorescence allows effective management with corticosteroids, emollients, and lifestyle modifications, leading to significant improvement and symptom resolution.
Romana Riyaz   +4 more
wiley   +1 more source

Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss–Newton Method

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 770-780, April 2025.
ABSTRACT Grazoprevir (GZR), a direct‐acting agent for hepatitis C virus, is recognized as a substrate for organic anion transporting polypeptide 1B (OATP1B), cytochrome P450 3A (CYP3A), and P‐glycoprotein (P‐gp). The objective of the present study was to elucidate the contribution of these molecules to the nonlinear pharmacokinetics of GZR using a ...
Takashi Yoshikado   +5 more
wiley   +1 more source

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