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The Conserved Glu in the Cyclotide Cycloviolacin O2 Has a Key Structural Role
, 2009 Cyclotides are a large family of plant peptides that are characterised by a head-to-tail circular backbone and three disulfide bonds that are arranged in a cystine knot. This unique structural feature, which is referred to as a cyclic cystine knot, gives
Haugaard-Jonsson, Linda M. +17 more
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Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
Natural Products and BioprospectingPeptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are a notable class, yet their distribution, diversity, and targets remain underexplored. Here, eleven tropical Psychotria species were
Roland Hellinger +6 more
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Peptides are promising drug modalities that can modulate protein–protein interactions, but their application is hampered by their limited ability to reach intracellular targets.
Yen-Hua Huang (409275) +10 more
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, 2004 The cyclotides are a family of disulfide-rich proteins from plants. They have the characteristic structural features of a circular protein backbone and a knotted arrangement of disulfide bonds. Structural and biochemical studies of the cyclotides suggest
David J Craik +14 more
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Microbial Cell FactoriesThe expanding field of site-specific ligation of proteins and peptides has catalyzed the development of novel methods that enhance molecular modification.
Avinash Kumar Singh +3 more
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Scientific ReportsChronic wounds represent a longstanding clinical problem due to impaired angiogenesis due to insufficient activation of vascular endothelial growth factor receptor 2 (VEGFR2).
Özlem Karaca Ocak, Nouman Ali
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Interaction of cyclotides and bacteria : A study of the cyclotide action and the bacterial reaction
, 2017 The growing problem of antibiotic resistance and the lack of promising prospective antibiotics have forced us to search for new classes of antibiotics. Among the candidates to develop into future antibacterials are antimicrobial peptides (AMPs). These potent, broad spectrum compounds are important components of innate immunity of organism from all ...
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Cyclotides are a family of plant-derived proteins that are characterized by a cyclic backbone and a knotted disulfide topology. Their cyclic cystine knot (CCK) motif makes them exceptionally resistant to thermal, chemical, and enzymatic degradation ...
Jacobsson, Erik, +7 more
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The Journal of Organic Chemistry, 2011
Cyclotides are head-to-tail cyclic peptides that contain a cystine knot motif built from six conserved cysteine residues. They occur in plants of the Rubiaceae, Violaceae, Cucurbitaceae, and Fabaceae families and, aside from their natural role in host defense, have a range of interesting pharmaceutical activities, including anti-HIV activity.
Craik, David J., Conibear, Anne C.
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Cyclotides are head-to-tail cyclic peptides that contain a cystine knot motif built from six conserved cysteine residues. They occur in plants of the Rubiaceae, Violaceae, Cucurbitaceae, and Fabaceae families and, aside from their natural role in host defense, have a range of interesting pharmaceutical activities, including anti-HIV activity.
Craik, David J., Conibear, Anne C.
openaire +5 more sources