Results 91 to 100 of about 578 (154)

The involvement of cyclotides in the heavy metal tolerance of Viola spp.

Scientific Reports
The Violaceae family is rich in metal-tolerant species and species producing cyclic peptides (cyclotides) that are linked to the resistance to biotic factors.
Klaudia Sychta, Aneta Słomka, Reza Shariatgorji, Per E. Andrén, Sławomir Samardakiewicz, Ulf Göransson, Blazej Slazak   +6 more
doaj   +1 more source

Identification of Cyclotides From Butterfly Pea () Petals and Its Biological Activities

Natural Product Communications
Background Cyclotides are macrocyclic peptides characterized by a head-to-tail cyclized backbone and a cyclic cystine knot motif, and are found in the petals of butterfly pea ( Clitoria ternatea ). Objective Clitoria ternatea cv. “Theparatpailin 63” is a
Naoki Ikeda, Hikari Matsumura, Arisa Kajiwara, Yukihiko Nakagawa, Machiko Kondo, Ken-ichi Kubo, Akihisa Tsuji, Fang-Sik Che   +7 more
doaj   +1 more source

Design of a Novel Cyclotide-Based CXCR4 Antagonist with Anti-Human Immunodeficiency Virus (HIV)-1 Activity

, 2012
Herein, we report for the first time the design and synthesis of a novel cyclotide able to efficiently inhibit HIV-1 viral replication by selectively targeting cytokine receptor CXCR4.
Debyser, Zeger, Neamati, Nouri, Shekhtman, Alexander, Christ, Frauke, Camarero, Julio A., Majumder, Subhabrata, Aboye, Teshome L., Ha, Helen   +7 more
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The identification of gene coding cyclotide from viola species and investigation of antimicrobial activities of extracted cyclotides

, 2017
Background and aim:Cyclotides are plant polypeptides characterized by their unique cyclic cysteine knot structural motif. They are present in many plants from the Violaceae, Rubiaceae and Cucurbitaceae families.
Zarabi, Mahboube, Roshan, Akram, Pakdel, Mona, Asgarani, Ezat, Rouini, Mahsa   +4 more
core  

Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold

, 2019
Oral activity has been described for cyclotide-containing traditional medicines, and demonstrated for reengineered cyclotides bearing grafted therapeutic epitopes, highlighting their potential for translation to the clinic.
Kan, Meng-Wei, Huang, Yen-Hua, Craik, David J., Poth, Aaron G., Le, Thao T.   +4 more
core   +1 more source

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

, 2009
Cyclotides are a family of plant defense proteins that are highly resistant to adverse chemical, thermal, and enzymatic treatment. Here, we present the first crystal structure of a cyclotide, varv F, from the European field pansy, Viola arvensis ...
Sjogren, T, Wang, C. K., Goransson, U, Sjögren, Tove,, Bohlin, Lars,, Martin, Jennifer L, Wang, Conan, Tan, N. H., Wang, Conan K., Martin, Jennifer L., Craik, D. J., Goransson, Ulf, Rosengren, K. Johan,, Craik, David J, Bohlin, Lars, Martin, J. L., Tan, Ning-Hua, Göransson, Ulf,, Rosengren, K Johan, Bohlin, L, Hu, S. H., Sjogren, Tove, Rosengren, K. Johan, Tang, Jun, Claeson, Per, Tang, J, Rosengren, K Johan,, Martin, Jennifer, Claeson, Per,, Tan, Nin-hua, Craik, David J., Tan, Ninghua, Hu, Shu-Hong, Hajdu, Janos,, Rosengren, K. J., Wang, Conan K, Hajdu, Janos, Hajdu, J, Claeson, P   +38 more
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Orientation and location of the cyclotide kalata B1 in lipid bilayers revealed by solid-state NMR

, 2017
Cyclotides are ultra-stable cyclic disulfide-rich peptides from plants. Their biophysical effects and medically interesting activities are related to their membrane-binding properties, with particularly high affinity for phosphatidylethanolamine lipids ...
Constantin Schalck, Ulrich, Anne S., Stephan L. Grage, Anne S. Ulrich, Henriques, Sonia Troeira, Pavel K. Mykhailiuk, Sónia Troeira Henriques, David J. Craik, Komarov, Igor V., Mylne, Joshua S., Schalck, Constantin, Mykhailiuk, Pavel K., Sani, Marc-Antoine, Grage, Stephan L., Sergii Afonin, Cheneval, Olivier, Olivier Cheneval, Marc-Antoine Sani, Ralf Heinzmann, Separovic, Frances, Craik, David J., Frances Separovic, Heinzmann, Ralf, Igor V. Komarov, Joshua S. Mylne, Afonin, Sergii   +25 more
core   +1 more source

Characterization and evaluation of cytotoxic and antimicrobial activities of cyclotides from Viola japonica

Scientific Reports
Cyclotides are a type of defense peptide most commonly found in the Violaceae family of plants, exhibiting various biological activities. In this study, we focused on the Viola japonica as our research subject and conducted transcriptome sequencing and ...
Yuanyuan Lian, Xue Tang, Gehui Hu, Chenfang Miao, Yunfei Cui, Dongting Zhangsun, Yong Wu, Sulan Luo   +7 more
doaj   +1 more source

Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis

Industrial Crops and Products
Cyclotides are plant-derived cyclic peptides recognized for their crucial role in host defense against insects and fungal pathogens. They are characterized by an ultra-stable head-to-tail cyclic backbone and a cystine knot formed by three conserved ...
Negin Khatibi, Olivier Ndogo Eteme, Conan K. Wang, Edward K. Gilding, Ernestine Nkwengoua Zondegoumba, Michelle L. Colgrave, Yen-Hua Huang, David J. Craik   +7 more
doaj   +1 more source

Cyclotide discovery in Gentianales revisited—identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants

, 2013
Cyclotides are a unique class of ribosomally synthesized cysteine-rich miniproteins characterized by a head-to-tail cyclized backbone and three conserved disulfide-bonds in a knotted arrangement. Originally they were discovered in the coffee-family plant
Carpenter, Eric J., Greger, Harald, Gruber, Christian W., Attah, Alfred F., Wong, Gane Ka-Shu, Kutchan, Toni M., Rolf, Megan, Sonibare, Mubo A., Moody, Jones O., Hellinger, Roland, Dessein, Steven, Koehbach, Johannes, Berger, Andreas   +12 more
core   +1 more source