Results 71 to 80 of about 578 (154)

Cyclotide structure-activity relationships: qualitative and quantitative approaches linking cytotoxic and anthelmintic activity to the clustering of physicochemical forces.

PLoS ONE, 2014
Cyclotides are a family of plant-derived proteins that are characterized by a cyclic backbone and a knotted disulfide topology. Their cyclic cystine knot (CCK) motif makes them exceptionally resistant to thermal, chemical, and enzymatic degradation ...
Sungkyu Park, Adam A Strömstedt, Ulf Göransson   +2 more
doaj   +1 more source

Display Technologies for Expanding the Pharmaceutical Applications of Cyclotides

Israel Journal of Chemistry, Volume 64, Issue 8-9, September 2024.
Abstract Cyclotides are ultra‐stable peptides originally discovered in plants based on their medicinal applications. Their natural function is as host defence agents. They are amenable to chemical synthesis for use as scaffolds for drug design applications.
Jing Xie, Meng‐Wei Kan, Simon J. de Veer, Conan Wang, David J. Craik   +4 more
wiley   +1 more source

Cyclotides prediction in Leptopetalum biflorum based on de novo transcriptome assembly and annotation

Journal of Holistic Integrative Pharmacy
Objective: There is a scarcity of transcriptome sequencing data available for the Leptopetalum biflorum, and numerous cyclotides remain undiscovered.
Xi Liu, Linlin Cai, Zhiming Zhou, Peiming Huang, Zhonglu Ren   +4 more
doaj   +1 more source

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

Frontiers in Plant Science, 2019
The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant interest based on its agricultural and medical applications, which range from use as a fodder and nitrogen fixing crop, to applications in food coloring and ...
Georgianna K. Oguis, Edward K. Gilding, Mark A. Jackson, David J. Craik   +3 more
doaj   +1 more source

Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics

ChemPlusChem, Volume 89, Issue 8, August 2024.
The idea of grafting small peptide pharmacophores onto larger protein scaffolds, thus harvesting the advantages of both, has given rise to a variety of protein engineering strategies that are reviewed herein. We also describe our own “Lasso‐Grafting” approach, which combines traditional grafting concepts with mRNA display to streamline the production ...
Mikio Imai, Kilian Colas, Hiroaki Suga
wiley   +1 more source

Computational modeling of cyclotides as antimicrobial agents against Neisseria gonorrhoeae PorB porin protein: integration of docking, immune, and molecular dynamics simulations

Frontiers in Chemistry
BackgroundNeisseria gonorrhoeae is the bacterium responsible for gonorrhoea, one of the most common sexually transmitted infections (STIs) globally. In 2020, the World Health Organization (WHO) estimated 82.4 million new cases of Neisseria gonorrhoeae ...
Muzamal Hussain, Muzamal Hussain, Nazia Kanwal, Alishba Jahangir, Nouman Ali, Nimra Hanif, Obaid Ullah   +6 more
doaj   +1 more source

Strategies of plants to overcome abiotic and biotic stresses

Biological Reviews, Volume 99, Issue 4, Page 1524-1536, August 2024.
ABSTRACT In their environment, plants are exposed to a multitude of abiotic and biotic stresses that differ in intensity, duration and severity. As sessile organisms, they cannot escape these stresses, but instead have developed strategies to overcome them or to compensate for the consequences of stress exposure.
Baoguo Du, Robert Haensch, Saleh Alfarraj, Heinz Rennenberg   +3 more
wiley   +1 more source

Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis

, 2020
Clitoria ternatea a perennial climber of the Fabaceae family, is well known for its agricultural and medical applications. It is also currently the only known member of the Fabaceae family that produces abundant amounts of the ultra-stable macrocyclic ...
Balaram, Padmanabhan, Venkatesan, Radhika, Sowdhamini, Ramanathan, Kalmankar, Neha V.   +3 more
core   +1 more source

Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae

Frontiers in Plant Science, 2015
During the last decade there has been increasing interest in small circular proteins found in plants of the violet family (Violaceae). These so-called cyclotides consist of a circular chain of approximately 30 amino acids, including six cysteines forming
Robert eBurman, Mariamawit Y Yeshak, Mariamawit Y Yeshak, Sonny eLarsson, David J. Craik, K. Johan Rosengren, K. Johan Rosengren, Ulf eGöransson   +7 more
doaj   +1 more source

Molecular farming for sustainable production of clinical‐grade antimicrobial peptides

Plant Biotechnology Journal, Volume 22, Issue 8, Page 2282-2300, August 2024.
Summary Antimicrobial peptides (AMPs) are emerging as next‐generation therapeutics due to their broad‐spectrum activity against drug‐resistant bacterial strains and their ability to eradicate biofilms, modulate immune responses, exert anti‐inflammatory effects and improve disease management. They are produced through solid‐phase peptide synthesis or in
Shahid Chaudhary, Zahir Ali, Magdy Mahfouz   +2 more
wiley   +1 more source