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Cyclotides [PDF]

Journal of Evidence-Based Complementary & Alternative Medicine, 2012
In recent years, a number of peptides containing a cyclic structural fold have been described. Among them, the cyclotides family was widely reported in different plant tissues, being composed of small cyclic peptides containing 6 conserved cysteine ...
Michelle F. S. Pinto, Renato G. Almeida, William F. Porto, Isabel C. M. Fensterseifer, Loiane A. Lima, Simoni C. Dias PhD, Octávio L. Franco PhD   +6 more
doaj   +5 more sources

Host-Defense Activities of Cyclotides [PDF]

Toxins, 2012
Cyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine
David J. Craik
doaj   +7 more sources

On chip microfluidic separation of cyclotides. [PDF]

Turk J Chem, 2023
<p>Cyclotides as a cyclic peptide produced by different groups of plants have been a very attractive field of research due to their exceptional properties in biological activities and drug design applications.
Didarian R, Ebrahimi A, Ghorbanpoor H, Bagheroghli H, Dogan Güzel F, Farhadpour M, Lotfibakhshayesh N, Hashempour H, Avci H.   +8 more
europepmc   +6 more sources

The involvement of cyclotides in the heavy metal tolerance of Viola spp. [PDF]

Scientific Reports
The Violaceae family is rich in metal-tolerant species and species producing cyclic peptides (cyclotides) that are linked to the resistance to biotic factors.
Klaudia Sychta, Aneta Słomka, Reza Shariatgorji, Per E. Andrén, Sławomir Samardakiewicz, Ulf Göransson, Blazej Slazak   +6 more
doaj   +3 more sources

Cyclotides as tools in chemical biology [PDF]

Accounts of Chemical Research, 2017
Conspectus Among the various molecules that plants produce for defense against pests and pathogens, cyclotides stand out as exceptionally stable and structurally unique.
Joachim Weidmann, David J. Craik, de Veer, Simon J., Craik, David J., Simon J. de Veer, Weidmann, Joachim   +5 more
core   +5 more sources

Cyclotides as novel plant-derived scaffolds for orally active cyclic peptide therapeutics [PDF]

Molecules and Cells
: Cyclotides are a group of plant-derived small peptides, characterized by a head-to-tail cyclic backbone and 3 conserved cysteine knots. The unique structure endows cyclotides with exceptional chemical stability and intrinsic cell-penetrating capacities,
Youbong Hyun
doaj   +2 more sources

Interpopulational Variation in Cyclotide Production in Heavy-Metal-Treated Pseudometallophyte (Viola tricolor L.) [PDF]

Plants
It remains an open question whether violets use universal mechanisms, such as the production of metallothioneins, phytochelatins, and organic acids and/or rely on specific mechanisms like the production of antimicrobial cyclic peptides (cyclotides) for ...
Rebecca Miszczak, Blazej Slazak, Klaudia Sychta, Ulf Göransson, Anna Nilsson, Aneta Słomka   +5 more
doaj   +2 more sources

Cyclotides as drug design scaffolds [PDF]

Current Opinion in Chemical Biology, 2017
Cyclotides are ultra-stable peptides derived from plants. They are around 30 amino acids in size and are characterized by their head-to-tail cyclic backbone and cystine knot.
Junqiao Du, Du, Junqiao, David J Craik, Craik, David J.   +3 more
core   +5 more sources

Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens. [PDF]

J Nat Prod, 2023
[Image: see text] Cyclotides are an intriguing class of structurally stable circular miniproteins of plant origin with numerous potential pharmaceutical and agricultural applications.
Rajendran S, Slazak B, Mohotti S, Muhammad T, Strömstedt AA, Kapusta M, Wilmowicz E, Göransson U, Hettiarachchi CM, Gunasekera S.   +9 more
europepmc   +2 more sources

Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells [PDF]

Biomedicines
Glioblastoma (GBM) is the most aggressive cancer originating in the brain, but unfortunately combination treatments with resection, radiation, and chemotherapy are relatively ineffective. Therefore, novel methods of adjuvant therapy are critically needed.
Samantha L. Gerlach, James S. Metcalf, Rachael A. Dunlop, Sandra Anne Banack, Cheenou Her, Viswanathan V. Krishnan, Ulf Göransson, Sunithi Gunasekera, Blazej Slazak, Paul Alan Cox   +9 more
doaj   +2 more sources