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Overview on the discovery and applications of cyclotides
, 2015 Cyclotides are bioactive peptides from plants that are characterized by their head-to-tail cyclic backbone and knotted arrangement of their three conserved disulfide bonds. Their natural function is thought to be as host defense agents and a single plant
David J. Craik, Craik, David J.
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Cyclotides as templates in drug design
Drug Discovery Today, 2010 Cyclotides are remarkably stable proteins from plants that have a range of pharmaceutical and agricultural applications based on both their various bioactivities and their potential for use as stable protein-engineering templates.
Troeira Henriques, Sónia +2 more
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Computational modeling of cyclotides as antimicrobial agents against Neisseria gonorrhoeae PorB porin protein: integration of docking, immune, and molecular dynamics simulations [PDF]
Frontiers in ChemistryBackgroundNeisseria gonorrhoeae is the bacterium responsible for gonorrhoea, one of the most common sexually transmitted infections (STIs) globally. In 2020, the World Health Organization (WHO) estimated 82.4 million new cases of Neisseria gonorrhoeae ...
Muzamal Hussain +6 more
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Cystine knot folding in cyclotides
, 2011 Cyclotides are naturally occurring plant-based proteins of approximately 30 amino acids in size that contain a head-to-tail cyclized backbone and a cystine knot motif formed by their three conserved disulfide bonds. Their exceptional stability and unique
Ulf Göransson +7 more
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Discovery, structure and biological activities of cyclotides
Advanced Drug Delivery Reviews, 2009 Cyclotides are small disulfide-rich peptides that are characterized by a head-to-tail cyclized peptide backbone and a knotted arrangement of three conserved disulfide bonds.
Daly, N.L . +8 more
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Cyclotides in a biotechnological context: opportunities and challenges
, 2015 Plant biotechnology offers us the ability to augment and improve upon biological systems to produce value added crops, medicines, or specialized products.
Mark A. Jackson +3 more
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Transgenic Innovation: Harnessing Cyclotides as Next Generation Pesticides [PDF]
ACS OmegaSathira Deegala +3 more
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Computational Design of Hypothetical New Peptides Based on a Cyclotide Scaffold as HIV gp120 Inhibitor. [PDF]
PLoS ONE, 2015 Cyclotides are a family of triple disulfide cyclic peptides with exceptional resistance to thermal/chemical denaturation and enzymatic degradation. Several cyclotides have been shown to possess anti-HIV activity, including kalata B1 (KB1).
Apiwat Sangphukieo +4 more
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Plants, 2022 Cyclotides are macrocycle peptides produced by plants from several families, including Violaceae. These compounds have the potential for applications in medicine, bioengineering and crop protection thanks to their multiple biological activities.
Blazej Slazak +6 more
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In vitro Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor
Frontiers in Pharmacology, 2022 Since viral infectious diseases continue to be a global health threat, new antiviral drugs are urgently needed. A unique class of therapeutic compounds are antimicrobial peptides (AMPs). They can be found in humans, bacteria and plants.
Carina Conzelmann +4 more
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