Results 11 to 20 of about 1,652 (193)
Characterization and evaluation of cytotoxic and antimicrobial activities of cyclotides from Viola japonica [PDF]
Scientific ReportsCyclotides are a type of defense peptide most commonly found in the Violaceae family of plants, exhibiting various biological activities. In this study, we focused on the Viola japonica as our research subject and conducted transcriptome sequencing and ...
Yuanyuan Lian +7 more
doaj +2 more sources
Pharmaceutical applications of cyclotides
Drug Discovery Today, 2019 Cyclotides are cyclic peptides, present in several plant families, that show diverse biological properties. Structurally, cyclotides share a distinctive head-to-tail circular knotted topology of three disulfide bonds.
Franco, Octávio L. +2 more
core +3 more sources
Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae
Frontiers in Plant Science, 2015 During the last decade there has been increasing interest in small circular proteins found in plants of the violet family (Violaceae). These so-called cyclotides consist of a circular chain of approximately 30 amino acids, including six cysteines forming
Robert eBurman +7 more
doaj +3 more sources
, 2015 It has been 20 years since the cyclic cystine-knotted compounds, called cyclotides, tied our knot with the violets. This chapter, above all, is a lucid summary of the twists, turns, knots, and rings in the relationship that followed.
Ulf Göransson +5 more
core +2 more sources
Comprehensive Mapping of Cyclotides from Viola philippica by Using Mass Spectrometry-Based Strategy [PDF]
MoleculesCyclotides are plant cyclic peptides with exceptional stability and diverse bioactivity, making them promising candidates for biomedical applications. Therefore, the study of cyclotides has attracted increasing attention in recent years.
Liyan Yu +6 more
doaj +2 more sources
Molecular Dynamics Simulations Cyclotide Kalata B1 Interactions with Lipid Bilayers [PDF]
MoleculesCyclotides are exceptionally stable plant peptides whose biological activity is widely attributed to interactions with lipid membranes, yet the molecular mechanisms underlying these interactions remain incompletely resolved.
Neville Y. Forlemu +4 more
doaj +2 more sources
Isolation and characterization of cytotoxic cyclotides from Viola philippica
Peptides, 2011 Cyclotides are a large family of plant peptides characterized by a macrocyclic backbone and knotted arrangement of three disulfide bonds. This unique structure renders cyclotides exceptionally stable to thermal, chemical and enzymatic treatments.
Lai Yue Chan +2 more
exaly +2 more sources
, 2015 Cyclotides are small disulfide-rich plant peptides. Their unique structural features, intrinsic bioactivities, and enormous sequence diversity make them interesting molecules for pharmaceutical applications.
Gruber, Christian W. +3 more
core +5 more sources
Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development [PDF]
Molecules, 2022 This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are relatively
Binu Jacob +3 more
doaj +2 more sources
A Comprehensive Review on the Anticancer Activity of Plant Peptides and Their Mechanisms of Action [PDF]
FoodsPlant-derived peptides have become one of the most promising classes of compounds in cancer research due to their specificity, safety, and different therapeutic actions.
Tianyu Hou +5 more
doaj +2 more sources