Results 21 to 30 of about 1,652 (193)
Isolation and characterization of cytotoxic cyclotides from Viola tricolor
Peptides, 2010 Many plants of the Violaceae plant family have been used in traditional remedies, and these plants often contain cyclotides, a particular type of plant cyclopeptide that is distinguished by a cyclic cystine knot motif.
Jun Tang, Conan K Wang, Wenyan Xu
exaly +2 more sources
Discovery and applications of the plant cyclotides
Toxicon, 2010 The cyclotides are a family of plant-derived proteins that occur in plants from the Violaceae (violet), Rubiaceae (coffee) and Cucurbitaceae (cucurbit) families and have a diverse range of biological activities, including uterotonic, anti-HIV ...
Craik, David J.
core +8 more sources
Cyclotides as natural anti-HIV agents [PDF]
Peptide Science, 2008 Cyclotides are disulfide rich macrocyclic plant peptides that are defined by their unique topology in which a head-to-tail cyclized backbone is knotted by the interlocking arrangement of three disulfide bonds.
Ireland, David C. +9 more
core +6 more sources
Cyclotides: Overview and Biotechnological Applications [PDF]
ChemBioChem, 2017 AbstractCyclotides are globular microproteins with a unique head‐to‐tail cyclized backbone, stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone topology and knotted arrangement of three disulfide bonds makes them exceptionally stable to chemical, thermal, and biological degradation compared to other peptides of ...
Julio A Camarero
exaly +3 more sources
Design and therapeutic applications of cyclotides
Future Medicinal Chemistry, 2009 Cyclotides are plant-derived peptides with a cyclic backbone and knotted topology of disulfide bonds. Their extreme stability and natural sequence variation has led to the suggestion that they might be useful as scaffolds to stabilize bioactive sequences.
Daly, Norelle L., Craik, David J.
core +6 more sources
Frontiers in Plant Science, 2018 Cyclotides are cyclic plant polypeptides of 27–37 amino acid residues. They have been extensively studied in bioengineering and drug development contexts. However, less is known about the relevance of cyclotides for the plants producing them.
Blażej Slazak +2 more
exaly +3 more sources
Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptides [PDF]
Nature CommunicationsThe legume albumin-1 gene family, arising after nodulation, encodes linear a- and b-chain peptides for nutrient storage and defense. Intriguingly, in one prominent legume, Clitoria ternatea, the b-chains are replaced by domains producing ultra-stable ...
Edward K. Gilding +9 more
doaj +2 more sources
Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense [PDF]
Planta, 2016 The distribution of cyclotides was visualized in plant cells, tissues and organs using immunohistochemistry. Finding of cyclotides in tissues potentially vulnerable to pathogen attacks supports their role as defense molecules.
Blażej Slazak +2 more
exaly +2 more sources
Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis [PDF]
Scientific ReportsChronic wounds represent a longstanding clinical problem due to impaired angiogenesis due to insufficient activation of vascular endothelial growth factor receptor 2 (VEGFR2).
Özlem Karaca Ocak, Nouman Ali
doaj +2 more sources
The chemistry and biology of cyclotides
ChemInform, 2007 Cyclotides are mini-proteins with a macrocyclic peptide backbone and cystine-knot arrangement of disulfide bonds that makes them exceptionally stable to chemical, thermal or enzymatic degradation.
Cemazar, M., Daly, N. L., Craik, D. J.
core +5 more sources