Results 1 to 10 of about 155,737 (137)

Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells [PDF]

Biomedicines
Glioblastoma (GBM) is the most aggressive cancer originating in the brain, but unfortunately combination treatments with resection, radiation, and chemotherapy are relatively ineffective. Therefore, novel methods of adjuvant therapy are critically needed.
Samantha L. Gerlach, James S. Metcalf, Rachael A. Dunlop, Sandra Anne Banack, Cheenou Her, Viswanathan V. Krishnan, Ulf Göransson, Sunithi Gunasekera, Blazej Slazak, Paul Alan Cox   +9 more
doaj   +10 more sources

Dynamic scenario of membrane binding process of kalata b1. [PDF]

PLoS ONE, 2014
Kalata B1 (kB1), a cyclotide that has been used in medical applications, displays cytotoxicity related to membrane binding and oligomerization. Our molecular dynamics simulation results demonstrate that Trp19 in loop 5 of both monomeric and tetrameric ...
Wanapinun Nawae, Supa Hannongbua, Marasri Ruengjitchatchawalya   +2 more
doaj   +7 more sources

Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate [PDF]

Biopolymers, 2016
This study provides a new method for quantifying the cyclotide kalata B1 in both plasma and brain homogenate. Cyclotides are ultra-stable peptides with three disulfide bonds that are interesting from a drug development perspective as they can be used as ...
Erik Melander, Ulf Göransson, Margareta Hammarlund-Udenaes   +2 more
exaly   +8 more sources

Molecular dynamics exploration of poration and leaking caused by Kalata B1 in HIV-infected cell membrane compared to host and HIV membranes [PDF]

Scientific Reports, 2017
The membrane disruption activities of kalata B1 (kB1) were investigated using molecular dynamics simulations with membrane models. The models were constructed to mimic the lipid microdomain formation in membranes of HIV particle, HIV-infected cell, and ...
Wanapinun Nawae, Supa Hannongbua, Marasri Ruengjitchatchawalya   +2 more
doaj   +7 more sources

The Biological Activity of the Prototypic Cyclotide Kalata B1 Is Modulated by the Formation of Multimeric Pores [PDF]

Journal of Biological Chemistry, 2009
The cyclotides are a large family of circular mini-proteins containing a cystine knot motif. They are expressed in plants as defense-related proteins, with insecticidal activity.
Yen-Hua Huang, Michelle L Colgrave, Norelle L Daly   +2 more
exaly   +10 more sources

Insights into Processing and Cyclization Events Associated with Biosynthesis of the Cyclic Peptide Kalata B1 [PDF]

Journal of Biological Chemistry, 2012
Plant cyclotides are the largest family of gene-encoded cyclic proteins. They act as host defense molecules to protect plants and are promising candidates as insecticidal and nematocidal agents in agriculture.
Brendon Conlan, Michelle L Colgrave, David J Craik   +2 more
exaly   +11 more sources

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR. [PDF]

Biophys J, 2017
Cyclotides are ultra-stable cyclic disulfide-rich peptides from plants. Their biophysical effects and medically interesting activities are related to their membrane-binding properties, with particularly high affinity for phosphatidylethanolamine lipids ...
Grage SL, Sani MA, Cheneval O, Henriques ST, Schalck C, Heinzmann R, Mylne JS, Mykhailiuk PK, Afonin S, Komarov IV, Separovic F, Craik DJ, Ulrich AS.   +12 more
europepmc   +9 more sources

Exploring the Limits of Cyanobactin Macrocyclase PatGmac: Cyclization of PawS-Derived Peptide Sunflower Trypsin Inhibitor-1 and Cyclotide Kalata B1. [PDF]

J Nat Prod, 2023
The subtilisin-like macrocyclase PatGmac is produced by the marine cyanobacterium Prochloron didemni. This enzyme is involved in the last step of the biosynthesis of patellamides, a cyanobactin type of ribosomally expressed and post-translationally ...
Muhammad T, Houssen WE, Thomas L, Alexandru-Crivac CN, Gunasekera S, Jaspars M, Göransson U.   +6 more
europepmc   +7 more sources

Molecular Dynamics Simulations Cyclotide Kalata B1 Interactions with Lipid Bilayers [PDF]

Molecules
Cyclotides are exceptionally stable plant peptides whose biological activity is widely attributed to interactions with lipid membranes, yet the molecular mechanisms underlying these interactions remain incompletely resolved.
Neville Y. Forlemu, Eric N. Njabon, Ajay Mallia, Simon Mwongela, Sairam Tangirala   +4 more
doaj   +4 more sources

A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor. [PDF]

Chembiochem, 2011
Featuring a circular, knotted structure and diverse bioactivities, cyclotides are a fascinating family of peptides that have inspired applications in drug design. Most likely evolved to protect plants against pests and herbivores, cyclotides also exhibit
Sando L, Henriques ST, Foley F, Simonsen SM, Daly NL, Hall KN, Gustafson KR, Aguilar MI, Craik DJ.   +8 more
europepmc   +8 more sources